Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells

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Efficacy of RNA polymerase II inhibitors in targeting dormant leukaemia cells

Background Dormant cells are characterised by low RNA synthesis. In contrast, cancer cells can be addicted to high RNA synthesis, including synthesis of survival molecules. We hypothesised that dormant cancer cells, already low in RNA, might be sensitive to apoptosis induced by RNA Polymerase II (R...

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Bibliographic Details
Main Authors:	Pallis, Monica, Burrows, Francis, Whittall, Abigail, Boddy, Nicholas, Seedhouse, Claire, Russell, Nigel
Format:	Article
Published:	BioMed Central 2013
Subjects:	Leukemia Dormancy RNA polymerase II inhibitors
Online Access:	https://eprints.nottingham.ac.uk/2459/

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