Heavy and light roles: myosin in the morphogenesis of the heart
Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies suggest that both myosin heavy-chain and myosin lightchain proteins are required fo...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Published: |
Springer
2013
|
| Online Access: | https://eprints.nottingham.ac.uk/2453/ |
| _version_ | 1848790789777260544 |
|---|---|
| author | England, Jennifer Loughna, Siobhan |
| author_facet | England, Jennifer Loughna, Siobhan |
| author_sort | England, Jennifer |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies
suggest that both myosin heavy-chain and myosin lightchain
proteins are required for a correctly formed heart.
Myosins are structural proteins that are not only expressed
from early stages of heart development, but when mutated
in humans they may give rise to congenital heart defects.
This review will discuss the roles of myosin, specifically
with regards to the developing heart. The expression of
each myosin protein will be described, and the effects that
altering expression has on the heart in embryogenesis in
different animal models will be discussed. The human
molecular genetics of the myosins will also be reviewed. |
| first_indexed | 2025-11-14T18:18:12Z |
| format | Article |
| id | nottingham-2453 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:18:12Z |
| publishDate | 2013 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-24532020-05-04T20:19:22Z https://eprints.nottingham.ac.uk/2453/ Heavy and light roles: myosin in the morphogenesis of the heart England, Jennifer Loughna, Siobhan Myosin is an essential component of cardiac muscle, from the onset of cardiogenesis through to the adult heart. Although traditionally known for its role in energy transduction and force development, recent studies suggest that both myosin heavy-chain and myosin lightchain proteins are required for a correctly formed heart. Myosins are structural proteins that are not only expressed from early stages of heart development, but when mutated in humans they may give rise to congenital heart defects. This review will discuss the roles of myosin, specifically with regards to the developing heart. The expression of each myosin protein will be described, and the effects that altering expression has on the heart in embryogenesis in different animal models will be discussed. The human molecular genetics of the myosins will also be reviewed. Springer 2013-04 Article PeerReviewed England, Jennifer and Loughna, Siobhan (2013) Heavy and light roles: myosin in the morphogenesis of the heart. Cellular and Molecular Life Science, 70 (7). pp. 1221-1239. ISSN 1420-682X http://www.ncbi.nlm.nih.gov/pubmed/22955375 doi:10.1007/s00018-012-1131-1 doi:10.1007/s00018-012-1131-1 |
| spellingShingle | England, Jennifer Loughna, Siobhan Heavy and light roles: myosin in the morphogenesis of the heart |
| title | Heavy and light roles: myosin in the morphogenesis of the heart |
| title_full | Heavy and light roles: myosin in the morphogenesis of the heart |
| title_fullStr | Heavy and light roles: myosin in the morphogenesis of the heart |
| title_full_unstemmed | Heavy and light roles: myosin in the morphogenesis of the heart |
| title_short | Heavy and light roles: myosin in the morphogenesis of the heart |
| title_sort | heavy and light roles: myosin in the morphogenesis of the heart |
| url | https://eprints.nottingham.ac.uk/2453/ https://eprints.nottingham.ac.uk/2453/ https://eprints.nottingham.ac.uk/2453/ |