Fluoxetine counteracts the cognitive and cellular effects of 5-Fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery

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Fluoxetine counteracts the cognitive and cellular effects of 5-Fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery

5-Fluorouracil (5-FU) is a cytostatic drug associated with chemotherapy-induced cognitive impairments that many cancer patients experience after treatment. Previous work in rodents has shown that 5-FU reduces hippocampal cell proliferation, a possible mechanism for the observed cognitive impairmen...

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Bibliographic Details
Main Authors:	Lyons, Laura, ELBeltagy, Maha, Bennett, Geoffrey, Wigmore, Peter
Format:	Article
Published:	Public Library of Science 2012
Online Access:	https://eprints.nottingham.ac.uk/2430/

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