Rate of transmission: a major determinant of the cost of clinical mastitis
The aim of this research was to use probabilistic sensitivity analysis to evaluate the relative importance of different components of a model designed to estimate the cost of clinical mastitis (CM). A particular focus was placed on the importance of pathogen transmission relative to other facto...
| Main Authors: | , , |
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| Format: | Article |
| Published: |
American Dairy Science Association
2013
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| Online Access: | https://eprints.nottingham.ac.uk/2427/ |
| _version_ | 1848790782725586944 |
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| author | Down, P.M. Green, Martin J. Hudson, C.D. |
| author_facet | Down, P.M. Green, Martin J. Hudson, C.D. |
| author_sort | Down, P.M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The aim of this research was to use probabilistic sensitivity
analysis to evaluate the relative importance of
different components of a model designed to estimate
the cost of clinical mastitis (CM). A particular focus
was placed on the importance of pathogen transmission
relative to other factors, such as milk price or
treatment costs. A stochastic Monte Carlo model was
developed to simulate a case of CM at the cow level and
to calculate the associated costs for 5 defined treatment
protocols. The 5 treatment protocols modeled were 3 d
of antibiotic intramammary treatment, 5 d of antibiotic
intramammary treatment, 3 d of intramammary and
systemic antibiotic treatment, 3 d of intramammary
and systemic antibiotic treatment plus 1 d of nonsteroidal
antiinflammatory drug treatment, and 5 d of
intramammary and systemic antibiotic treatment. Uniform
distributions were used throughout the model to
enable investigation of the cost of CM over a spectrum
of clinically realistic scenarios without specifying which
scenario was more or less likely. A risk of transmission
parameter distribution, based on literature values, was
included to model the effect of pathogen transmission
to uninfected cows, from cows that remained subclinically
infected after treatment for CM. Spearman rank
correlation coefficients were used to evaluate the relationships
between model input values and the estimated
cost of CM. Linear regression models were used to
explore the effect that changes to specific independent
variables had on the cost of CM. Risk of transmission
was found to have the strongest association with the
cost of CM, followed by bacteriological cure rate, cost of
culling, and yield loss. Other factors such as milk price,
cost of labor, and cost of medicines were of minimal
influence in comparison. The cost of CM was similar for
all 5 treatment protocols. The results from this study
suggest that, when seeking to minimize the economic
impact of CM in dairy herds, great emphasis should be
placed on the reduction of pathogen transmission from
cows with CM to uninfected cows. |
| first_indexed | 2025-11-14T18:18:05Z |
| format | Article |
| id | nottingham-2427 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:18:05Z |
| publishDate | 2013 |
| publisher | American Dairy Science Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-24272020-05-04T20:18:39Z https://eprints.nottingham.ac.uk/2427/ Rate of transmission: a major determinant of the cost of clinical mastitis Down, P.M. Green, Martin J. Hudson, C.D. The aim of this research was to use probabilistic sensitivity analysis to evaluate the relative importance of different components of a model designed to estimate the cost of clinical mastitis (CM). A particular focus was placed on the importance of pathogen transmission relative to other factors, such as milk price or treatment costs. A stochastic Monte Carlo model was developed to simulate a case of CM at the cow level and to calculate the associated costs for 5 defined treatment protocols. The 5 treatment protocols modeled were 3 d of antibiotic intramammary treatment, 5 d of antibiotic intramammary treatment, 3 d of intramammary and systemic antibiotic treatment, 3 d of intramammary and systemic antibiotic treatment plus 1 d of nonsteroidal antiinflammatory drug treatment, and 5 d of intramammary and systemic antibiotic treatment. Uniform distributions were used throughout the model to enable investigation of the cost of CM over a spectrum of clinically realistic scenarios without specifying which scenario was more or less likely. A risk of transmission parameter distribution, based on literature values, was included to model the effect of pathogen transmission to uninfected cows, from cows that remained subclinically infected after treatment for CM. Spearman rank correlation coefficients were used to evaluate the relationships between model input values and the estimated cost of CM. Linear regression models were used to explore the effect that changes to specific independent variables had on the cost of CM. Risk of transmission was found to have the strongest association with the cost of CM, followed by bacteriological cure rate, cost of culling, and yield loss. Other factors such as milk price, cost of labor, and cost of medicines were of minimal influence in comparison. The cost of CM was similar for all 5 treatment protocols. The results from this study suggest that, when seeking to minimize the economic impact of CM in dairy herds, great emphasis should be placed on the reduction of pathogen transmission from cows with CM to uninfected cows. American Dairy Science Association 2013-10 Article PeerReviewed Down, P.M., Green, Martin J. and Hudson, C.D. (2013) Rate of transmission: a major determinant of the cost of clinical mastitis. Journal of Dairy Science, 96 (10). pp. 6301-6314. ISSN 0022-0302 http://www.journalofdairyscience.org/article/S0022-0302(13)00555-9/abstract doi:10.3168/jds.2012-6470 doi:10.3168/jds.2012-6470 |
| spellingShingle | Down, P.M. Green, Martin J. Hudson, C.D. Rate of transmission: a major determinant of the cost of clinical mastitis |
| title | Rate of transmission: a major determinant of the cost of clinical mastitis |
| title_full | Rate of transmission: a major determinant of the cost of clinical mastitis |
| title_fullStr | Rate of transmission: a major determinant of the cost of clinical mastitis |
| title_full_unstemmed | Rate of transmission: a major determinant of the cost of clinical mastitis |
| title_short | Rate of transmission: a major determinant of the cost of clinical mastitis |
| title_sort | rate of transmission: a major determinant of the cost of clinical mastitis |
| url | https://eprints.nottingham.ac.uk/2427/ https://eprints.nottingham.ac.uk/2427/ https://eprints.nottingham.ac.uk/2427/ |