The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments

QR Code

The effects of a telomere destabilising agent on cancer cell-cycle dynamics - integrated modelling and experiments

The pentacyclic acridinium salt RHPS4 displays anti-tumour properties in vitro as well as in vivo and is potentially cell-cycle specific. We have collected experimental data and formulated a compartmental model using ordinary differential equations to investigate how the compound affects cells in ea...

Full description

Bibliographic Details
Main Authors:	Hirt, Bartholomäus V., Wattis, Jonathan A.D., Preston, Simon P., Laughton, Charles A.
Format:	Article
Published:	Elsevier 2012
Online Access:	https://eprints.nottingham.ac.uk/2395/

Similar Items

Mathematical modelling of cell cycle and telomere dynamics
by: Hirt, Bartholomäus V.
Published: (2013)

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs
by: Hirt, Bartholomäus V., et al.
Published: (2014)

Performance interfaces and destabilisation
by: Reeves, Stuart, et al.
Published: (2004)

Mathematical modelling of telomere dynamics
by: Qi, Qi
Published: (2011)

Bile acids destabilise HIF-1a and promote anti-tumour phenotypes in cancer cell models.
by: Phelan, J., et al.
Published: (2016)

Inhibiting protein–protein interactions in telomeres as an approach to cancer chemotherapy
by: Salih, Twana
Published: (2016)

Telomeres and brain health
by: Podlasek, Anna
Published: (2022)

Nanoparticle synthesis and the addition of group IV elements for the destabilisation of magnesium hydride
by: Chaudhary, Anna-Lisa
Published: (2013)

New directions for hydrogen storage: Sulphur destabilised sodium aluminium hydride
by: Sheppard, Drew, et al.
Published: (2013)

Telomere, telomerase and liver disease
by: Aravinthan, Aloysious D., et al.
Published: (2017)

Exploring halide destabilised calcium hydride as a high-temperature thermal battery
by: Sofianos, M. Veronica, et al.
Published: (2020)

Concentrating Solar Thermal storage using metal hydride: Study of destabilised calcium hydrides
by: Griffond, Arnaud Camille Maurice
Published: (2019)

High-temperature thermochemical energy storage using metal hydrides: Destabilisation of calcium hydride with silicon
by: Griffond, Arnaud C.M., et al.
Published: (2021)

Cloning and characterisation of telomeric DNA from Cladosporium fulvum
by: Coleman, M., et al.
Published: (1993)

Telomere biology in the freshwater planarian Schmidtea mediterranea
by: Tan, Thomas Ching-Jen
Published: (2011)

Ageing and the telomere connection: An intimate relationship with inflammation
by: Zhang, J., et al.
Published: (2016)

Exact solutions for cluster-growth kinetics with evolving size and shape profiles
by: Wattis, Jonathan A.D.
Published: (2006)

An introduction to mathematical models of coagulation-fragmentation processes: a discrete deterministic mean-field approach
by: Wattis, Jonathan A.D.
Published: (2006)

Similarity solutions of a Becker-Döring system with time-dependent monomer input
by: Wattis, Jonathan A.D.
Published: (2004)

Nonlinear breathing modes at a defect
by: Wattis, Jonathan A.D.
Published: (2004)

Shape of transition layers in a differential--delay equation
by: Wattis, Jonathan A.D.
Published: (2017)

Potential association of nicotinamide on the telomerase activity and telomere length mediated by PARP-1 mechanism in myeloid cancer
by: Nur Rasyidah Muhammad,, et al.
Published: (2020)

The effect on melanoma risk of genes previously associated with telomere length
by: Iles, M., et al.
Published: (2014)

Identification of seven loci affecting mean telomere length and their association with disease
by: Codd, V., et al.
Published: (2013)

Telomere maintenance and telomerase activity are differentially regulated in asexual and sexual worms
by: Tan, Thomas C.J., et al.
Published: (2012)

Genes required to maintain telomeres in the absence of telomerase in Saccharomyces cerevisiae
by: Alotaibi, Mohammad Kdaimes H.
Published: (2012)

Chiral polymerisation and the RNA world
by: Wattis, Jonathan A.D., et al.
Published: (2005)

Coarse-graining and renormalisation group methods for the elucidation of the kinetics of complex nucleation and growth processes
by: Coveney, Peter V., et al.
Published: (2006)

Symmetry-breaking in chiral polymerisation
by: Wattis, Jonathan A.D., et al.
Published: (2005)

Chiral polymerisation and the RNA world
by: Wattis, Jonathan A.D., et al.
Published: (2005)

Effect of consumption of bee products on telomere lenght and longevity of life in beekeepers
by: Mohamad Nasir, Nurul Fatihah
Published: (2015)

Thermodynamic Destabilisation of MgH2 and NaMgH3 using Group IV elements Si, Ge and Sn
by: Chaudhary, Anna-Lisa, et al.
Published: (2015)

ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator
by: Jahn, A., et al.
Published: (2017)

Random sequential adsorption with two components: asymptotic analysis and finite size effects
by: Reeve, Louise, et al.
Published: (2015)

Bayesian model selection for the glacial-interglacial cycle
by: Carson, Jake, et al.
Published: (2017)

Genetically determined telomeres shortening is associated with carotid atherosclerosis progression and increased incidence of cardiovascular events
by: Baragetti, A., et al.
Published: (2016)

Apparent ploidy effects on silencing are post-transcriptional at HML and telomeres in saccharomyces cerevisiae
by: McLaughlan, Jenny M., et al.
Published: (2012)

Measurement of Leukocyte telomere length with various modifications to Cawthon's method: a review
by: Al-Battawi, Samer, et al.
Published: (2022)

Discrete breathers in a two-dimensional hexagonal Fermi-Pasta-Ulam lattice
by: Butt, Imran A., et al.
Published: (2007)

Asymptotic analysis of combined breather-kink modes in a Fermi-Pasta-Ulam chain
by: Butt, Imran A., et al.
Published: (2007)