Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor

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Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor

β-blockers are widely used to improve symptoms and prolong life in heart disease primarily by inhibiting the actions of endogenous catecholamines at the β1-adrenoceptor. There are two common naturally occurring polymorphisms within the human β1-adrenoceptor sequence: Ser or Gly at position 49 in the...

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Bibliographic Details
Main Authors:	Baker, Jillian G., Hill, Stephen J., Proudman, Richard G.W.
Format:	Article
Published:	Public Library of Science 2013
Online Access:	https://eprints.nottingham.ac.uk/2360/

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