Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantative comparison of cellular and cardiovascular pharmacological responses

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Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantative comparison of cellular and cardiovascular pharmacological responses

β-Adrenoceptor antagonists differ in their degree of partial agonism. In vitro assays have provided information on ligand affinity, selectivity, and intrinsic efficacy. However, the extent to which these properties are manifest in vivo is less clear. Conscious freely moving rats, instrumented for me...

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Bibliographic Details
Main Authors:	Baker, Jillian G., Kemp, Philip, March, Julie, Fretwell, Laurice, Hill, Stephen J., Gardiner, Sheila M.
Format:	Article
Published:	Federation of American Society of Experimental Biology 2011
Subjects:	β-adrenoceptor Partial agonism Intrinsic sympathomimetic activity Heart rate Vascular conductance
Online Access:	https://eprints.nottingham.ac.uk/2359/

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