Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia
The following study used 3-T functional magnetic resonance imaging (fMRI) to investigate the neural signature of Kamin blocking. Kamin blocking is an associative learning phenomenon seen where prior association of a stimulus (A) with an outcome blocks subsequent learning to an added stimulus (B) whe...
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Public Library of Science
2012
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| Online Access: | https://eprints.nottingham.ac.uk/2326/ |
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| author | Moran, Paula M. Rouse, Jennifer L. Cross, Benjamin Corcoran, Rhiannon Schürmann, Martin |
| author_facet | Moran, Paula M. Rouse, Jennifer L. Cross, Benjamin Corcoran, Rhiannon Schürmann, Martin |
| author_sort | Moran, Paula M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The following study used 3-T functional magnetic resonance imaging (fMRI) to investigate the neural signature of Kamin blocking. Kamin blocking is an associative learning phenomenon seen where prior association of a stimulus (A) with an outcome blocks subsequent learning to an added stimulus (B) when both stimuli are later presented together (AB) with the same outcome. While there are a number of theoretical explanations of Kamin blocking, it is widely considered to exemplify the use of prediction error in learning, where learning occurs in proportion to the difference between expectation and outcome. In Kamin blocking as stimulus A fully predicts the outcome no prediction error is generated by the addition of stimulus B to form the compound stimulus AB, hence learning about it is “blocked”. Kamin blocking is disrupted in people with schizophrenia, their relatives and healthy individuals with high psychometrically-defined schizotypy. This disruption supports suggestions that abnormal prediction error is a core deficit that can help to explain the symptoms of schizophrenia. The present study tested 9 healthy volunteers on an f-MRI adaptation of Oades' “mouse in the house task”, the only task measuring Kamin blocking that shows disruption in schizophrenia patients that has been independently replicated. Participant's Kamin blocking scores were found to inversely correlate with Kamin-blocking-related activation within the prefrontal cortex, specifically the medial frontal gyrus. The medial frontal gyrus has been associated with the psychological construct of uncertainty, which we suggest is consistent with disrupted Kamin blocking and demonstrated in people with schizophrenia. These data suggest that the medial frontal gyrus merits further investigation as a potent |
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| format | Article |
| id | nottingham-2326 |
| institution | University of Nottingham Malaysia Campus |
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| last_indexed | 2025-11-14T18:17:40Z |
| publishDate | 2012 |
| publisher | Public Library of Science |
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| spelling | nottingham-23262020-05-04T16:33:40Z https://eprints.nottingham.ac.uk/2326/ Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia Moran, Paula M. Rouse, Jennifer L. Cross, Benjamin Corcoran, Rhiannon Schürmann, Martin The following study used 3-T functional magnetic resonance imaging (fMRI) to investigate the neural signature of Kamin blocking. Kamin blocking is an associative learning phenomenon seen where prior association of a stimulus (A) with an outcome blocks subsequent learning to an added stimulus (B) when both stimuli are later presented together (AB) with the same outcome. While there are a number of theoretical explanations of Kamin blocking, it is widely considered to exemplify the use of prediction error in learning, where learning occurs in proportion to the difference between expectation and outcome. In Kamin blocking as stimulus A fully predicts the outcome no prediction error is generated by the addition of stimulus B to form the compound stimulus AB, hence learning about it is “blocked”. Kamin blocking is disrupted in people with schizophrenia, their relatives and healthy individuals with high psychometrically-defined schizotypy. This disruption supports suggestions that abnormal prediction error is a core deficit that can help to explain the symptoms of schizophrenia. The present study tested 9 healthy volunteers on an f-MRI adaptation of Oades' “mouse in the house task”, the only task measuring Kamin blocking that shows disruption in schizophrenia patients that has been independently replicated. Participant's Kamin blocking scores were found to inversely correlate with Kamin-blocking-related activation within the prefrontal cortex, specifically the medial frontal gyrus. The medial frontal gyrus has been associated with the psychological construct of uncertainty, which we suggest is consistent with disrupted Kamin blocking and demonstrated in people with schizophrenia. These data suggest that the medial frontal gyrus merits further investigation as a potent Public Library of Science 2012-08-31 Article PeerReviewed Moran, Paula M., Rouse, Jennifer L., Cross, Benjamin, Corcoran, Rhiannon and Schürmann, Martin (2012) Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia. PLoS ONE, 7 (8). e43905/1-e43905/7. ISSN 1932-6203 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0043905 doi:10.1371/journal.pone.0043905 doi:10.1371/journal.pone.0043905 |
| spellingShingle | Moran, Paula M. Rouse, Jennifer L. Cross, Benjamin Corcoran, Rhiannon Schürmann, Martin Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia |
| title | Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia |
| title_full | Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia |
| title_fullStr | Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia |
| title_full_unstemmed | Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia |
| title_short | Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia |
| title_sort | kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia |
| url | https://eprints.nottingham.ac.uk/2326/ https://eprints.nottingham.ac.uk/2326/ https://eprints.nottingham.ac.uk/2326/ |