Investigation of epimer formation in amide coupling reactions: an experiment for advanced undergraduate students

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Investigation of epimer formation in amide coupling reactions: an experiment for advanced undergraduate students

An experiment is described to investigate how the choice of coupling agent and reaction conditions affects the ratio of epimers formed in the sensitive amide-coupling reaction between N-Boc or N-benzoyl (R)-phenylglycine and (S)-valine methyl ester. The experiment, which is suitable for third-year...

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Bibliographic Details
Main Author:	Fray, Michael J.
Format:	Article
Published:	American Chemical Society, Division of Chemical Education 2014
Subjects:	Upper-Division Undergraduate Laboratory Instruction Organic Chemistry Collaborative/Cooperative Learning Hands-On Learning/Manipulatives Inquiry-Based/Discovery Learning Amides Amino Acids Diastereomers NMR Spectroscopy
Online Access:	https://eprints.nottingham.ac.uk/2283/

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