Investigation of epimer formation in amide coupling reactions: an experiment for advanced undergraduate students
An experiment is described to investigate how the choice of coupling agent and reaction conditions affects the ratio of epimers formed in the sensitive amide-coupling reaction between N-Boc or N-benzoyl (R)-phenylglycine and (S)-valine methyl ester. The experiment, which is suitable for third-year...
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| Format: | Article |
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American Chemical Society, Division of Chemical Education
2014
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| Online Access: | https://eprints.nottingham.ac.uk/2283/ |