Simulating the dynamics of T cell subsets throughout the lifetime
It is widely accepted that the immune system undergoes age-related changes correlating with increased disease in the elderly. T cell subsets have been implicated. The aim of this work is firstly to implement and validate a simulation of T regulatory cell (Treg) dynamics throughout the lifetime, bas...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Book Section |
| Published: |
Springer
2011
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| Online Access: | https://eprints.nottingham.ac.uk/2027/ |
| _version_ | 1848790707990429696 |
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| author | Foan, Stephanie Jackson, Andrew M. Spendlove, Ian Aickelin, Uwe |
| author2 | Liò, Pietro |
| author_facet | Liò, Pietro Foan, Stephanie Jackson, Andrew M. Spendlove, Ian Aickelin, Uwe |
| author_sort | Foan, Stephanie |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | It is widely accepted that the immune system undergoes age-related changes correlating with increased disease in the elderly. T cell subsets have been implicated. The aim of this work is firstly to implement and validate a simulation
of T regulatory cell (Treg) dynamics throughout the lifetime, based on a model by Baltcheva. We show that our initial simulation produces an inversion between
precursor and mature Tregs at around 20 years of age, though the output differs significantly from the original laboratory dataset. Secondly, this report discusses
development of the model to incorporate new data from a cross-sectional study of healthy blood donors addressing balance between Tregs and Th17 cells with novel markers for Treg. The potential for simulation to add insight into immune aging is discussed. |
| first_indexed | 2025-11-14T18:16:54Z |
| format | Book Section |
| id | nottingham-2027 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:16:54Z |
| publishDate | 2011 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-20272020-05-04T20:23:52Z https://eprints.nottingham.ac.uk/2027/ Simulating the dynamics of T cell subsets throughout the lifetime Foan, Stephanie Jackson, Andrew M. Spendlove, Ian Aickelin, Uwe It is widely accepted that the immune system undergoes age-related changes correlating with increased disease in the elderly. T cell subsets have been implicated. The aim of this work is firstly to implement and validate a simulation of T regulatory cell (Treg) dynamics throughout the lifetime, based on a model by Baltcheva. We show that our initial simulation produces an inversion between precursor and mature Tregs at around 20 years of age, though the output differs significantly from the original laboratory dataset. Secondly, this report discusses development of the model to incorporate new data from a cross-sectional study of healthy blood donors addressing balance between Tregs and Th17 cells with novel markers for Treg. The potential for simulation to add insight into immune aging is discussed. Springer Liò, Pietro Nicosia, Giuseppe Stibor, Thomas 2011 Book Section PeerReviewed Foan, Stephanie, Jackson, Andrew M., Spendlove, Ian and Aickelin, Uwe (2011) Simulating the dynamics of T cell subsets throughout the lifetime. In: Artificial immune systems: 10th international conference, ICARIS 2011, Cambridge, UK, July 18-21, 2011: proceedings. Lecture notes in computer science (6825). Springer, Heidelberg, pp. 71-76. ISBN 9783642223716 http://link.springer.com/chapter/10.1007/978-3-642-22371-6_8 |
| spellingShingle | Foan, Stephanie Jackson, Andrew M. Spendlove, Ian Aickelin, Uwe Simulating the dynamics of T cell subsets throughout the lifetime |
| title | Simulating the dynamics of T cell subsets throughout the lifetime |
| title_full | Simulating the dynamics of T cell subsets throughout the lifetime |
| title_fullStr | Simulating the dynamics of T cell subsets throughout the lifetime |
| title_full_unstemmed | Simulating the dynamics of T cell subsets throughout the lifetime |
| title_short | Simulating the dynamics of T cell subsets throughout the lifetime |
| title_sort | simulating the dynamics of t cell subsets throughout the lifetime |
| url | https://eprints.nottingham.ac.uk/2027/ https://eprints.nottingham.ac.uk/2027/ |