Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans
Recent data suggest that there might be a subtle thermal explanation for the apparent induction by radiofrequency (RF) radiation of transgene expression from a small-heat-shock-protein (hsp16-1) promoter in the nematode, Caenorhabditis elegans. The RF fields used in the C. elegans study were much we...
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| Format: | Article |
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Wiley
2008
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| Online Access: | https://eprints.nottingham.ac.uk/1979/ |
| _version_ | 1848790696250572800 |
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| author | Dawe, Adam S. Nylund, Reeta Leszczynski, Dariusz Kuster, Niels Reader, Tom de Pomerai, David I. |
| author_facet | Dawe, Adam S. Nylund, Reeta Leszczynski, Dariusz Kuster, Niels Reader, Tom de Pomerai, David I. |
| author_sort | Dawe, Adam S. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Recent data suggest that there might be a subtle thermal explanation for the apparent induction by radiofrequency (RF) radiation of transgene expression from a small-heat-shock-protein (hsp16-1) promoter in the nematode, Caenorhabditis elegans. The RF fields used in the C. elegans study were much weaker (SAR 5-40 mW kg-1) than those routinely tested in many other published studies (SAR ~2 W kg-1). To resolve this disparity, we have exposed the same transgenic hsp16-1::lacZ strain of C. elegans (PC72) to higher intensity RF fields (1.8 GHz; SAR ~1.8 W kg-1). For both continuous wave (CW) and Talk-pulsed RF exposures (2.5 h at 25C), there was no indication that RF exposure could induce reporter expression above sham control levels. Thus, at much higher induced RF field strength (close to the maximum permitted exposure from a mobile telephone handset), this particular nematode heat-shock gene is not up-regulated. However, under conditions where background reporter expression was moderately elevated in the sham controls (perhaps as a result of some unknown co-stressor), we found some evidence that reporter expression may be reduced by ~15% following exposure to either Talk-pulsed or CW RF fields. |
| first_indexed | 2025-11-14T18:16:43Z |
| format | Article |
| id | nottingham-1979 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:16:43Z |
| publishDate | 2008 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-19792020-05-04T20:27:39Z https://eprints.nottingham.ac.uk/1979/ Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans Dawe, Adam S. Nylund, Reeta Leszczynski, Dariusz Kuster, Niels Reader, Tom de Pomerai, David I. Recent data suggest that there might be a subtle thermal explanation for the apparent induction by radiofrequency (RF) radiation of transgene expression from a small-heat-shock-protein (hsp16-1) promoter in the nematode, Caenorhabditis elegans. The RF fields used in the C. elegans study were much weaker (SAR 5-40 mW kg-1) than those routinely tested in many other published studies (SAR ~2 W kg-1). To resolve this disparity, we have exposed the same transgenic hsp16-1::lacZ strain of C. elegans (PC72) to higher intensity RF fields (1.8 GHz; SAR ~1.8 W kg-1). For both continuous wave (CW) and Talk-pulsed RF exposures (2.5 h at 25C), there was no indication that RF exposure could induce reporter expression above sham control levels. Thus, at much higher induced RF field strength (close to the maximum permitted exposure from a mobile telephone handset), this particular nematode heat-shock gene is not up-regulated. However, under conditions where background reporter expression was moderately elevated in the sham controls (perhaps as a result of some unknown co-stressor), we found some evidence that reporter expression may be reduced by ~15% following exposure to either Talk-pulsed or CW RF fields. Wiley 2008 Article PeerReviewed Dawe, Adam S., Nylund, Reeta, Leszczynski, Dariusz, Kuster, Niels, Reader, Tom and de Pomerai, David I. (2008) Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans. Bioelectromagnetics, 29 (2). pp. 92-99. ISSN 1521-186X http://onlinelibrary.wiley.com/doi/10.1002/bem.20366/abstract doi:10.1002/bem.20366 doi:10.1002/bem.20366 |
| spellingShingle | Dawe, Adam S. Nylund, Reeta Leszczynski, Dariusz Kuster, Niels Reader, Tom de Pomerai, David I. Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans |
| title | Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans |
| title_full | Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans |
| title_fullStr | Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans |
| title_full_unstemmed | Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans |
| title_short | Continuous Wave and simulated GSM exposure at 1.8 W/kg and 1.8 GHz do not induce hsp16-1 heat-shock gene expression in Caenorhabditis elegans |
| title_sort | continuous wave and simulated gsm exposure at 1.8 w/kg and 1.8 ghz do not induce hsp16-1 heat-shock gene expression in caenorhabditis elegans |
| url | https://eprints.nottingham.ac.uk/1979/ https://eprints.nottingham.ac.uk/1979/ https://eprints.nottingham.ac.uk/1979/ |