Phase-amplitude descriptions of neural oscillator models

Phase oscillators are a common starting point for the reduced description of many single neuron models that exhibit a strongly attracting limit cycle. The framework for analysing such models in response to weak perturbations is now particularly well advanced, and has allowed for the development of a...

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Main Authors: Wedgwood, Kyle C.A., Lin, Kevin K., Thul, Ruediger, Coombes, Stephen
Format: Article
Published: Springer 2013
Online Access:https://eprints.nottingham.ac.uk/1896/
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author Wedgwood, Kyle C.A.
Lin, Kevin K.
Thul, Ruediger
Coombes, Stephen
author_facet Wedgwood, Kyle C.A.
Lin, Kevin K.
Thul, Ruediger
Coombes, Stephen
author_sort Wedgwood, Kyle C.A.
building Nottingham Research Data Repository
collection Online Access
description Phase oscillators are a common starting point for the reduced description of many single neuron models that exhibit a strongly attracting limit cycle. The framework for analysing such models in response to weak perturbations is now particularly well advanced, and has allowed for the development of a theory of weakly connected neural networks. However, the strong-attraction assumption may well not be the natural one for many neural oscillator models. For example, the popular conductance based Morris-Lecar model is known to respond to periodic pulsatile stimulation in a chaotic fashion that cannot be adequately described with a phase reduction. In this paper, we generalise the phase description that allows one to track the evolution of distance from the cycle as well as phase on cycle. We use a classical technique from the theory of ordinary differential equations that makes use of a moving coordinate system to analyse periodic orbits. The subsequent phase-amplitude description is shown to be very well suited to understanding the response of the oscillator to external stimuli (which are not necessarily weak). We consider a number of examples of neural oscillator models, ranging from planar through to high dimensional models, to illustrate the effectiveness of this approach in providing an improvement over the standard phase-reduction technique. As an explicit application of this phase-amplitude framework, we consider in some detail the response of a generic planar model where the strong-attraction assumption does not hold, and examine the response of the system to periodic pulsatile forcing. In addition, we explore how the presence of dynamical shear can lead to a chaotic response.
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spelling nottingham-18962020-05-04T20:20:56Z https://eprints.nottingham.ac.uk/1896/ Phase-amplitude descriptions of neural oscillator models Wedgwood, Kyle C.A. Lin, Kevin K. Thul, Ruediger Coombes, Stephen Phase oscillators are a common starting point for the reduced description of many single neuron models that exhibit a strongly attracting limit cycle. The framework for analysing such models in response to weak perturbations is now particularly well advanced, and has allowed for the development of a theory of weakly connected neural networks. However, the strong-attraction assumption may well not be the natural one for many neural oscillator models. For example, the popular conductance based Morris-Lecar model is known to respond to periodic pulsatile stimulation in a chaotic fashion that cannot be adequately described with a phase reduction. In this paper, we generalise the phase description that allows one to track the evolution of distance from the cycle as well as phase on cycle. We use a classical technique from the theory of ordinary differential equations that makes use of a moving coordinate system to analyse periodic orbits. The subsequent phase-amplitude description is shown to be very well suited to understanding the response of the oscillator to external stimuli (which are not necessarily weak). We consider a number of examples of neural oscillator models, ranging from planar through to high dimensional models, to illustrate the effectiveness of this approach in providing an improvement over the standard phase-reduction technique. As an explicit application of this phase-amplitude framework, we consider in some detail the response of a generic planar model where the strong-attraction assumption does not hold, and examine the response of the system to periodic pulsatile forcing. In addition, we explore how the presence of dynamical shear can lead to a chaotic response. Springer 2013 Article PeerReviewed Wedgwood, Kyle C.A., Lin, Kevin K., Thul, Ruediger and Coombes, Stephen (2013) Phase-amplitude descriptions of neural oscillator models. Journal of Mathematical Neuroscience, 3 (2). ISSN 2190-8567 http://www.mathematical-neuroscience.com/content/3/1/2 doi:10.1186/2190-8567-3-2 doi:10.1186/2190-8567-3-2
spellingShingle Wedgwood, Kyle C.A.
Lin, Kevin K.
Thul, Ruediger
Coombes, Stephen
Phase-amplitude descriptions of neural oscillator models
title Phase-amplitude descriptions of neural oscillator models
title_full Phase-amplitude descriptions of neural oscillator models
title_fullStr Phase-amplitude descriptions of neural oscillator models
title_full_unstemmed Phase-amplitude descriptions of neural oscillator models
title_short Phase-amplitude descriptions of neural oscillator models
title_sort phase-amplitude descriptions of neural oscillator models
url https://eprints.nottingham.ac.uk/1896/
https://eprints.nottingham.ac.uk/1896/
https://eprints.nottingham.ac.uk/1896/