Activity of an antimicrobial hydrocephalus shunt catheter against Propionibacterium acnes
Shunt infection is a major complication affecting approximately 10% of procedures. Propionibacterium acnes, an anaerobic skin bacterium, is increasingly recognized as a shunt pathogen, causing up to 14% of infections. Though susceptible to penicillin and cephalosporins, P. acnes shunt infections are...
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| Format: | Article |
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American Society for Microbiology
2010
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| Online Access: | https://eprints.nottingham.ac.uk/1650/ |
| _version_ | 1848790646555410432 |
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| author | Bayston, Roger Vera, Litza Ashraf, Waheed |
| author_facet | Bayston, Roger Vera, Litza Ashraf, Waheed |
| author_sort | Bayston, Roger |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Shunt infection is a major complication affecting approximately 10% of procedures. Propionibacterium acnes, an anaerobic skin bacterium, is increasingly recognized as a shunt pathogen, causing up to 14% of infections. Though susceptible to penicillin and cephalosporins, P. acnes shunt infections are not preventable by means of perioperative prophylaxis, due to poor cerebrospinal fluid penetration. Antimicrobial shunts with activity against staphylococci are available, but their activity against P. acnes is unknown, and the study was designed to determine this. Three methods of evaluation were used in order to determine the emergence of resistance when exposure is to high inocula for long periods, the time taken to kill 100% of the bacteria attached to the shunt, and the duration of activity under constant flow conditions with repeated bacterial challenge. Despite repeated exposure to high bacterial inocula over 70 days, no resistance was seen. The time taken to kill all attached bacteria, 96 h, was twice that taken to kill attached staphylococci. Nevertheless, under constant flow conditions with repeated challenges, the antimicrobial catheters resisted colonization by P. acnes for 56 days. Using tests that were designed to be clinically predictive when done together, the results suggest that the antimicrobial catheters will be able to prevent colonization of hydrocephalus shunts by P. acnes. |
| first_indexed | 2025-11-14T18:15:55Z |
| format | Article |
| id | nottingham-1650 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:15:55Z |
| publishDate | 2010 |
| publisher | American Society for Microbiology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-16502020-05-04T20:24:42Z https://eprints.nottingham.ac.uk/1650/ Activity of an antimicrobial hydrocephalus shunt catheter against Propionibacterium acnes Bayston, Roger Vera, Litza Ashraf, Waheed Shunt infection is a major complication affecting approximately 10% of procedures. Propionibacterium acnes, an anaerobic skin bacterium, is increasingly recognized as a shunt pathogen, causing up to 14% of infections. Though susceptible to penicillin and cephalosporins, P. acnes shunt infections are not preventable by means of perioperative prophylaxis, due to poor cerebrospinal fluid penetration. Antimicrobial shunts with activity against staphylococci are available, but their activity against P. acnes is unknown, and the study was designed to determine this. Three methods of evaluation were used in order to determine the emergence of resistance when exposure is to high inocula for long periods, the time taken to kill 100% of the bacteria attached to the shunt, and the duration of activity under constant flow conditions with repeated bacterial challenge. Despite repeated exposure to high bacterial inocula over 70 days, no resistance was seen. The time taken to kill all attached bacteria, 96 h, was twice that taken to kill attached staphylococci. Nevertheless, under constant flow conditions with repeated challenges, the antimicrobial catheters resisted colonization by P. acnes for 56 days. Using tests that were designed to be clinically predictive when done together, the results suggest that the antimicrobial catheters will be able to prevent colonization of hydrocephalus shunts by P. acnes. American Society for Microbiology 2010-12 Article PeerReviewed Bayston, Roger, Vera, Litza and Ashraf, Waheed (2010) Activity of an antimicrobial hydrocephalus shunt catheter against Propionibacterium acnes. Antimicrobial Agents and Chemotherapy, 54 (12). pp. 5082-5085. ISSN 0066-4804 http://aac.asm.org/content/54/12/5082 doi:10.1128/AAC.00540-10 doi:10.1128/AAC.00540-10 |
| spellingShingle | Bayston, Roger Vera, Litza Ashraf, Waheed Activity of an antimicrobial hydrocephalus shunt catheter against Propionibacterium acnes |
| title | Activity of an antimicrobial hydrocephalus shunt catheter
against Propionibacterium acnes |
| title_full | Activity of an antimicrobial hydrocephalus shunt catheter
against Propionibacterium acnes |
| title_fullStr | Activity of an antimicrobial hydrocephalus shunt catheter
against Propionibacterium acnes |
| title_full_unstemmed | Activity of an antimicrobial hydrocephalus shunt catheter
against Propionibacterium acnes |
| title_short | Activity of an antimicrobial hydrocephalus shunt catheter
against Propionibacterium acnes |
| title_sort | activity of an antimicrobial hydrocephalus shunt catheter
against propionibacterium acnes |
| url | https://eprints.nottingham.ac.uk/1650/ https://eprints.nottingham.ac.uk/1650/ https://eprints.nottingham.ac.uk/1650/ |