Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications
Bioresorbable implants are an attractive alternative to metallic bone fixation devices and offer potential to eliminate some of the clinical challenges with the latter. This work explores the manufacturing of fully bioresorbable fibre-reinforced composite rods and screws for such applications. Poly...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
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2013
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| Online Access: | https://eprints.nottingham.ac.uk/14379/ |
| _version_ | 1848791946085007360 |
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| author | Felfel, Reda |
| author_facet | Felfel, Reda |
| author_sort | Felfel, Reda |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Bioresorbable implants are an attractive alternative to metallic bone fixation devices and offer potential to eliminate some of the clinical challenges with the latter. This work explores the manufacturing of fully bioresorbable fibre-reinforced composite rods and screws for such applications. Poly lactic acid (PLA) and phosphate glass fibres (PGF) were combined to provide mechanical reinforcement and biocompatibility characteristics. Aligned and randomly reinforced PLA/PGF composites were prepared by compression moulding prior to thermomechanical deformation into rod and screw forms. In vitro degradation and mechanical properties retention were investigated in phosphate buffered saline (PBS) at 37°C. The composite rods and screws exceeded published data for bioresorbable implants in their virgin state and were towards the upper range of cortical bone properties. The properties reduced rapidly in an aqueous medium and this was attributed to matrix plasticisation and fibre/matrix disbonding. The degraded samples maintained strength and stiffness close to the lower limits of the cortical bone. Water uptake and mass loss for composites exceeded equivalent values for PLA alone due to water wicking at the fibre/matrix interface. Ion release tests correlated linearly with mass loss profiles confirming that the dominant degradation mechanism was fibre dissolution. The PLA/PGF composites also exhibited good biocompatibility to human osteosarcoma and human mesenchymal stem cells. |
| first_indexed | 2025-11-14T18:36:35Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-14379 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T18:36:35Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-143792025-02-28T11:30:27Z https://eprints.nottingham.ac.uk/14379/ Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications Felfel, Reda Bioresorbable implants are an attractive alternative to metallic bone fixation devices and offer potential to eliminate some of the clinical challenges with the latter. This work explores the manufacturing of fully bioresorbable fibre-reinforced composite rods and screws for such applications. Poly lactic acid (PLA) and phosphate glass fibres (PGF) were combined to provide mechanical reinforcement and biocompatibility characteristics. Aligned and randomly reinforced PLA/PGF composites were prepared by compression moulding prior to thermomechanical deformation into rod and screw forms. In vitro degradation and mechanical properties retention were investigated in phosphate buffered saline (PBS) at 37°C. The composite rods and screws exceeded published data for bioresorbable implants in their virgin state and were towards the upper range of cortical bone properties. The properties reduced rapidly in an aqueous medium and this was attributed to matrix plasticisation and fibre/matrix disbonding. The degraded samples maintained strength and stiffness close to the lower limits of the cortical bone. Water uptake and mass loss for composites exceeded equivalent values for PLA alone due to water wicking at the fibre/matrix interface. Ion release tests correlated linearly with mass loss profiles confirming that the dominant degradation mechanism was fibre dissolution. The PLA/PGF composites also exhibited good biocompatibility to human osteosarcoma and human mesenchymal stem cells. 2013-03-15 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/14379/1/594977.pdf Felfel, Reda (2013) Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications. PhD thesis, University of Nottingham. Biomedical materials Fracture fixation Orthopaedic implants Fibre-reinforced composite rods and screws |
| spellingShingle | Biomedical materials Fracture fixation Orthopaedic implants Fibre-reinforced composite rods and screws Felfel, Reda Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications |
| title | Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications |
| title_full | Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications |
| title_fullStr | Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications |
| title_full_unstemmed | Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications |
| title_short | Manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications |
| title_sort | manufacture and characterisation of bioresorbable fibre reinforced composite rods and screws for bone fracture fixation applications |
| topic | Biomedical materials Fracture fixation Orthopaedic implants Fibre-reinforced composite rods and screws |
| url | https://eprints.nottingham.ac.uk/14379/ |