Development of assays for therapeutic screening in myotonic dystrophy

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Development of assays for therapeutic screening in myotonic dystrophy

Myotonic dystrophy (DM) is an autosomal dominant inherited multisystemic neuromuscular disease. The molecular mechanism for DM is mediated by toxic RNAs containing expanded repeat units. DMI is caused by a CTG repeat expansion in 3'-UTR of the DMPK gene while DM2 is caused by CCTG repeat in int...

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Bibliographic Details
Main Author:	Udosen, Inyang Udofia
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2012
Online Access:	https://eprints.nottingham.ac.uk/14282/

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