DNA damage response and anti-apoptotic proteins expression in NPMc+ mutated cells in acute myeloid leukaemia

QR Code

DNA damage response and anti-apoptotic proteins expression in NPMc+ mutated cells in acute myeloid leukaemia

Nucleophosmin 1 (NPM1) is a multi-functional phosphoprotein, which shuttles between the nucleolus and the cytoplasm. It participates in many cellular processes including ribosome biogenesis and transport, centrosome duplication, and also contributes to the control of genomic stability. NPM1 interact...

Full description

Bibliographic Details
Main Author:	Qutob, Haitham
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2014
Subjects:	DNA damage DNA repair Nucleophosmin 1 C-terminal mutations
Online Access:	https://eprints.nottingham.ac.uk/14209/

Similar Items

Assessment of DNA damage and DNA damage response and repair in dormancy-enriched leukemia cells
by: Aldosari, Sahar
Published: (2017)

Replication of damaged DNA
by: Upton, Amy Louise
Published: (2009)

Assessment of DNA-damage repair in breast cancer
by: Alshareeda, Alaa
Published: (2014)

Targeting ataxia telangiectasia-mutated and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized cancer therapy
by: Alsubhi, Nouf
Published: (2018)

Clinical and biological significance of RAD51 expression in breast cancer: a key DNA damage response protein
by: Alshareeda, Alaa, et al.
Published: (2016)

Targeting DNA damage repair pathways in breast and ovarian cancers
by: Singh, Youvica
Published: (2025)

Pre-clinical development of human apurinic/apyrimidinic endonuclease (APE1) inhibitors for cancer therapy
by: Mohammed, Mohammed Zubair Khuder
Published: (2011)

EXPLORING NOVEL MOLECULAR MECHANISMS OF HELQ IN DNA DAMAGE REPAIR
by: Pan, Jin Ke Michele
Published: (2024)

Investigating a human DNA repair helicase that supports CRISPR editing
by: Cubbon, Andrew
Published: (2022)

Multiple domain deletion towards 5’-3’ polymerase activity of DNA polymerase I from Geobacillus sp. strain SK72
by: Hadrawi, Waqiyuddin Hilmi
Published: (2021)

Crosstalk between transposase subunits during cleavage of the mariner transposon
by: Claeys Bouuaert, Corentin, et al.
Published: (2014)

Genome architecture and DNA replication in Haloferax volcanii
by: Marriott, Hannah
Published: (2018)

DNA repair in the archaea – an emerging picture
by: White, Malcolm F., et al.
Published: (2018)

Evaluation of DNA repair biomarkers in epithelial ovarian and breast cancers
by: Shoqafi, Ahmed
Published: (2025)

Interactions of the Bacillus subtilis DnaE polymerase with replisomal proteins modulate its activity and fidelity
by: Paschalis, Vasileios, et al.
Published: (2017)

Genetic and biochemical analysis of the Hel308 Helicase in the Archaeon Haloferax volcanii
by: Lever, Rebecca
Published: (2020)

Biochemical and genetic analysis of Lhr, a mysterious helicase/glycosylase conserved across species
by: Buckley, Ryan J.
Published: (2023)

The repair of DNA breaks in Escherichia coli and analysis of the bacterial recombination protein RecN
by: Wood, Stuart Robert
Published: (2009)

RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner
by: Parvathaneni, Swetha, et al.
Published: (2017)

Alternative DNA Repair During Meiosis in the Budding Yeast S. cerevisiae
by: Reeves, Ryan Peter
Published: (2025)

Structural and genetic analyses of the RdgC protein in Escherichia coli
by: Yu, Jing
Published: (2009)

Targeting DNA repair for personalisation of glioblastoma therapy
by: Perry, Christina Joy
Published: (2016)

Regulation of human heterochromatin protein 1 binding protein 3 (HP1BP3, also known as HP1BP74) in response to the DNA damage
by: Normatova, Makhliyo
Published: (2016)

The half-life of DNA in bone: measuring decay kinetics in 158 dated fossils
by: Allentoft, M., et al.
Published: (2012)

Targeting dormancy in acute myeloid leukaemia
by: Doolan, Lara
Published: (2023)

The Application of DNA Molecular Marker Techniques in Hevea Brasiliensis
by: Atan, Safiah
Published: (2001)

Investigating the potential role of DNA (hydroxy)methylation in the control of post-stroke axon growth
by: Wallis, Marcus
Published: (2020)

Genetic analysis of two structure-specific endonucleases Hef and Fen1 in archaeon Haloferax volcanii
by: Duan, Zhenhong
Published: (2009)

Targeting DNA repair and hypoxia to improve radioresponse in breast cancer
by: Aiyappa, Radhika
Published: (2020)

Carbon-14 decay as a source of non-canonical bases in DNA
by: Sassi, Michel, et al.
Published: (2013)

DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain
by: Northall, Sarah J., et al.
Published: (2017)

Repeat-Induced Point Mutation in Fungi: A Fungal-Specific Endogenous Mutagenesis Process
by: Hane, James, et al.
Published: (2015)

Development of DNA Based Technologies for Detection of Genetically Modified Organisms
by: Cheah, Yoke Kqueen
Published: (2006)

Calculating RIP mutation in fungal genomes using RIPCAL
by: Hane, James
Published: (2015)

Synthesis and characterisation of tetrabutylammonium bromide-based deep eutectic solvents for DNA solvation
by: Yusof, Rizana
Published: (2016)

Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia
by: Welch, Mathew, et al.
Published: (2013)

Analysis of catalytic and non-catalytic regions of the human DNA repair helicase HelQ
by: Jenkins, T
Published: (2021)

Targeting Ataxia telangiectasia mutated (ATM) and DNA dependent protein kinase catalytic subunit (DNA-PKcs) for synthetic lethality application in breast cancer
by: Albarakati, Nada
Published: (2015)

Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer
by: Neale, R., et al.
Published: (2014)

DNA Fingerprinting of Theobroma Cacao
by: Basherudin, Norlia
Published: (1998)