Fluoxetine prevents the cognitive and cellular effects of chemotherapy in the adult hippocampus

QR Code

Fluoxetine prevents the cognitive and cellular effects of chemotherapy in the adult hippocampus

Rationale: CMF (cyclophosphamide: CP; methotrexate: MTX; 5-fluorouracil: 5-FU) is a chemotherapy combination associated with the cognitive impairments which many cancer patients experience after treatment. A reduction in hippocampal neurogenesis is a known means by which cytotoxic drugs alter cognit...

Full description

Bibliographic Details
Main Author:	Lyons, Laura
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2011
Subjects:	Hippocampal neurogenesis Cognitive effects of chemotherapy Fluoxetine used in cancer treatment
Online Access:	https://eprints.nottingham.ac.uk/14038/

Similar Items

Impact of chemotherapy on hippocampal neurogenesis and potential protective strategies
by: Lasio, Valeria
Published: (2017)

The impact of 5-flurouracil on white matter tracts and possible protection by fluoxetine or indomethacin administration: in vivo and in vitro study
by: Al-Bayti, Ayoub Ali Hussein
Published: (2017)

High resolution imaging of the hippocampus at 7T
by: Adeyemi, Oluwatobi
Published: (2023)

Fluoxetine counteracts the cognitive and cellular effects of 5-Fluorouracil in the rat hippocampus by a mechanism of prevention rather than recovery
by: Lyons, Laura, et al.
Published: (2012)

In-vitro comparison of anticancer activity between pure gallic acid and gallic acid - iron oxide coated with polyethylene glycol nanoparticles
by: Rosman, Raihana
Published: (2018)

Vestibulotoxicity and balance problems associated with cisplatin chemotherapy in adult cancer survivors
by: Prayuenyong, Pattarawadee
Published: (2021)

The ongoing effects and impact of hearing loss and tinnitus associated with platinum based chemotherapy in adults living with and beyond cancer
by: Pearson, Stephanie
Published: (2022)

Keeping the balance - importance of balanced hippocampal neural activity for attention and memory
by: Gwilt, Miriam
Published: (2021)

Effect of 5-fluorouracil chemotherapy and the potential protective effect of the SSRI antidepressant fluoxetine on memory and neurogenesis in the adult hippocampus
by: EL-Beltagy, Maha
Published: (2010)

In vitro treatment of MCF-7 and MDA-MB-231 breast cancer cell lines with doxorubicin and vincristine sulphate calcium carbonate nanoparticles
by: Mengyi, Xue
Published: (2019)

Phosphate-based glass microspheres for bone repair and localised chemotherapy and radiotherapy treatment of bone cancers
by: Milborne, Ben
Published: (2023)

The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy
by: Storr, Sarah J., et al.
Published: (2016)

Can body composition be used to optimize the dose of platinum chemotherapy in lung cancer? A feasibility study
by: Crosby, Vincent, et al.
Published: (2016)

Effects of bortezomib on HIF-1 and HIF-2 transcriptional activities
by: Abd Aziz, Noraini
Published: (2013)

Ex vivo modelling of oesophago-gastric cancer
by: Saunders, John
Published: (2017)

The prognostic and predictive power of redox rotein expression for anthracycline-based chemotherapy response in locally advanced breast cancer
by: Woolston, Caroline M., et al.
Published: (2012)

An in vitro model of the impact of chemotherapy on neural stem cells and the protection provided by cells in the neurogenic niche
by: Rabiaa, Entedhar Kadhum Hussain
Published: (2018)

Targeting alternative splicing as a novel approach to chemotherapy induced peripheral neuropathy
by: Swift, Matthew N.
Published: (2021)

Id4 functional analysis during neurogenesis using zebrafish as a model organism
by: Girayer, Elif Naz
Published: (2017)

Factors influencing treatment selection and thirty-day mortality following chemotherapy for people with small cell lung cancer: an analysis of national audit data
by: Jones, Gavin S., et al.
Published: (2018)

Quality of life among breast cancer patients undergoing chemotherapy in Oncology Unit at Hospital Universiti Sains Malaysia
by: Azman, Wan Nur Atirah Wan
Published: (2013)

The impact of long-term vitamin D deficiency on the offspring metabolic health and cognitive function via epigenetic changes
by: Madi, Gulden
Published: (2023)

Controversial issues in the management of older adults with early breast cancer
by: Mislang, Anna Rachelle, et al.
Published: (2017)

The control of adult neural stem cell proliferation and cognition by valproic acid
by: Umka, Jariya.
Published: (2010)

Evaluation of immune cell infiltrates and expression of cytokines/biological molecules in the microenvironment of tumours and tumour-draining axillary lymph nodes in patients with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy: crucial contribution to immune-mediated tumour cell death
by: Kaewkangsadan, Viriya
Published: (2016)

Risk of venous thromboembolism in hospitalised cancer patients in England – A cohort study
by: Ratib, Sonia, et al.
Published: (2016)

Chemotherapeutics potential of matcha green tea(Camellia sinensis (L.) Kuntze) on weri-Rb-1 retinoblastoma cancer cells
by: Sayuti, Nor Hafiza
Published: (2022)

The role of exercise and NMNAT1 on functional and behavioural aspects of brain ageing in the mouse
by: Taylor, Helen Lynette
Published: (2019)

Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition
by: Elmorsy, Ekramy, et al.
Published: (2017)

Combatting chemoresistance: an analysis of DNA repair proteins ERCC1 and XPF and their chemotherapeutic implications in ovarian cancer
by: Griffin, Michaela
Published: (2019)

Neuro-behavioural impact of changes in hippocampal neural activity
by: Williams, Stuart
Published: (2021)

Identification of drug(s) selectively targeting colorectal cancer stem-like cells for differentiation (differentiation therapy)
by: Ahmed, Mehreen
Published: (2020)

Variation in the risk of venous thromboembolism in people with colorectal cancer: a population-based cohort study from England
by: Walker, A.J., et al.
Published: (2014)

Targeted therapy for cancer using pH-responsive nanocarrier systems
by: Manchun, S., et al.
Published: (2012)

Characterization, histological evaluation and efficacy of docetaxel-loaded cockle shellderived CaCO3 nanoparticles in vitro and in vivo
by: Hammadi, Nahidah Ibrahim
Published: (2018)

PARP inhibitor combinations with Olaparib for synergistic efficacy in Olaparib-resistant triple-negative breast cancer cells
by: Yusoh, Nur Aininie
Published: (2023)

The effectiveness of videoconference-based cognitive-behavioural therapy
by: Stubbings, Daniel R.
Published: (2012)

Audiologist-guided internet-based cognitive behavior therapy for adults with tinnitus in the United Kingdom: a randomized controlled trial
by: Beukes, Eldre W., et al.
Published: (2017)

Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis
by: Doherty, Fionn Dunphy, et al.
Published: (2017)

Cognitive stimulation therapy for dementia
by: Rai, Harleen, et al.
Published: (2018)