Developing a model system to investigate the epigenetic mechanisms underlying pluripotency in human cells

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Developing a model system to investigate the epigenetic mechanisms underlying pluripotency in human cells

Pluripotent human embryonic stem cells (hESCs) are a valuable tool for clinical therapies, drug testing and investigation of developmental pathways. Recently, over-expression of four pluripotency-associated genes (OCT4, NANOG, SOX2, and LIN28) has proven sufficient to reprogram differentiated cells...

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Bibliographic Details
Main Author:	Matsa, Elena
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2010
Subjects:	Cell differentiation Epigenesis Pluripotency transcription factors
Online Access:	https://eprints.nottingham.ac.uk/14019/

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