Palladium and copper mediated cross couplings using dialkylphosphites
Described herein are synthetic methodologies using palladium- and copper-mediated cross coupling reactions involving dialkylphosphites. Chapter 1 discloses two methods for producing alknylphophonates. The first is a novel palladium mediated cross coupling of alkynylbromides with dialkylphosphites....
| Main Author: | |
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2013
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| Online Access: | https://eprints.nottingham.ac.uk/13586/ |
| _version_ | 1848791767329013760 |
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| author | Fraser, Jamie |
| author_facet | Fraser, Jamie |
| author_sort | Fraser, Jamie |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Described herein are synthetic methodologies using palladium- and copper-mediated cross coupling reactions involving dialkylphosphites.
Chapter 1 discloses two methods for producing alknylphophonates. The first is a novel palladium mediated cross coupling of alkynylbromides with dialkylphosphites. The second is an improvement of a known aerobic copper mediated cross coupling using terminal alkynes and dialkylphosphites.
Chapter 2 discloses a novel aerobic copper mediated amide synthesis method.
Chapter 3 discloses a novel aerobic copper mediated phosphoramidate synthesis method.
All of the above developed methodologies were found to produce their respective products in acceptable yields and tolerate a wide range of functionality.
The experimental section comprises the practical methods for effecting the above reactions and the experimental data for all of the compounds presented herein. |
| first_indexed | 2025-11-14T18:33:44Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-13586 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T18:33:44Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-135862025-02-28T13:19:31Z https://eprints.nottingham.ac.uk/13586/ Palladium and copper mediated cross couplings using dialkylphosphites Fraser, Jamie Described herein are synthetic methodologies using palladium- and copper-mediated cross coupling reactions involving dialkylphosphites. Chapter 1 discloses two methods for producing alknylphophonates. The first is a novel palladium mediated cross coupling of alkynylbromides with dialkylphosphites. The second is an improvement of a known aerobic copper mediated cross coupling using terminal alkynes and dialkylphosphites. Chapter 2 discloses a novel aerobic copper mediated amide synthesis method. Chapter 3 discloses a novel aerobic copper mediated phosphoramidate synthesis method. All of the above developed methodologies were found to produce their respective products in acceptable yields and tolerate a wide range of functionality. The experimental section comprises the practical methods for effecting the above reactions and the experimental data for all of the compounds presented herein. 2013-10-15 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/13586/1/thesis_final_corrections.pdf Fraser, Jamie (2013) Palladium and copper mediated cross couplings using dialkylphosphites. PhD thesis, University of Nottingham. |
| spellingShingle | Fraser, Jamie Palladium and copper mediated cross couplings using dialkylphosphites |
| title | Palladium and copper mediated cross couplings using dialkylphosphites |
| title_full | Palladium and copper mediated cross couplings using dialkylphosphites |
| title_fullStr | Palladium and copper mediated cross couplings using dialkylphosphites |
| title_full_unstemmed | Palladium and copper mediated cross couplings using dialkylphosphites |
| title_short | Palladium and copper mediated cross couplings using dialkylphosphites |
| title_sort | palladium and copper mediated cross couplings using dialkylphosphites |
| url | https://eprints.nottingham.ac.uk/13586/ |