Investigating the nature of the secondary binding site of the human β1-adrenoceptor using fluorescent ligands and confocal microscopy

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Investigating the nature of the secondary binding site of the human β1-adrenoceptor using fluorescent ligands and confocal microscopy

CGP 12177 is a high affinity β-blocker that antagonises agonist responses mediated through the catecholamine binding site of the human β1-adrenoceptor (β1AR). However, CGP 12177 also exerts agonist activity through a secondary, low affinity “CGP 12177” binding site/conformational state of the β1AR....

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Bibliographic Details
Main Author:	Gherbi, Karolina
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2013
Online Access:	https://eprints.nottingham.ac.uk/13426/

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