Small molecule inhibitors of the p53-MDM2 protein-protein interaction

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Small molecule inhibitors of the p53-MDM2 protein-protein interaction

In Chapter 2, bis- and tris- arylsulfonamides, were investigated as possible inhibitors of the p53-MDM2 protein-protein interaction (PPI). The lead compound, 19, inhibited the PPI, in a fluorescence polarisation (FP) based competitive binding assay with ICso 26.4 pM and the most potent analogue, 66,...

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Bibliographic Details
Main Author:	Fitzgerald, Ross Patrick
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2011
Online Access:	https://eprints.nottingham.ac.uk/13136/

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