The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia
Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work BOLD/R2* CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst mai...
| Main Authors: | , , , , |
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| Format: | Article |
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Elsevier
2010
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| Online Access: | https://eprints.nottingham.ac.uk/1313/ |
| _version_ | 1848790583848468480 |
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| author | Driver, Ian Blockley, Nicholas Fisher, Joseph Francis, Susan Gowland, Penny A. |
| author_facet | Driver, Ian Blockley, Nicholas Fisher, Joseph Francis, Susan Gowland, Penny A. |
| author_sort | Driver, Ian |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work BOLD/R2* CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst maintaining a steady PETO2 level. Significant CVR was observed in both grey and white matter at both 3 & 7T, whilst an approximately linear relationship found between R2* CVR and field strength has implications for BOLD models and calibration. Grey matter R2* CVR was 0.066±0.004 s-1 mmHg-1 at 3T and 0.141±0.008 s-1mmHg-1 at 7T. White matter R2* CVR was 0.021±0.003 s-1mmHg-1 at 3T and 0.040±0.007 s-1mmHg-1 at 7T. |
| first_indexed | 2025-11-14T18:14:56Z |
| format | Article |
| id | nottingham-1313 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:14:56Z |
| publishDate | 2010 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-13132020-05-04T16:29:19Z https://eprints.nottingham.ac.uk/1313/ The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia Driver, Ian Blockley, Nicholas Fisher, Joseph Francis, Susan Gowland, Penny A. Mapping cerebrovascular reactivity (CVR) to hypercapnia is important both clinically and for improved understanding of the haemodynamic properties of the BOLD effect. In this work BOLD/R2* CVR was investigated by using a device which provided small, repeatable and stable steps in PETCO2, whilst maintaining a steady PETO2 level. Significant CVR was observed in both grey and white matter at both 3 & 7T, whilst an approximately linear relationship found between R2* CVR and field strength has implications for BOLD models and calibration. Grey matter R2* CVR was 0.066±0.004 s-1 mmHg-1 at 3T and 0.141±0.008 s-1mmHg-1 at 7T. White matter R2* CVR was 0.021±0.003 s-1mmHg-1 at 3T and 0.040±0.007 s-1mmHg-1 at 7T. Elsevier 2010-05-15 Article PeerReviewed Driver, Ian, Blockley, Nicholas, Fisher, Joseph, Francis, Susan and Gowland, Penny A. (2010) The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia. NeuroImage, 51 (1). pp. 274-279. ISSN 1053-8119 http://www.elsevier.com/locate/ynimg 10.1016/j.neuroimage.2009.12.113 10.1016/j.neuroimage.2009.12.113 10.1016/j.neuroimage.2009.12.113 |
| spellingShingle | Driver, Ian Blockley, Nicholas Fisher, Joseph Francis, Susan Gowland, Penny A. The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia |
| title | The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia |
| title_full | The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia |
| title_fullStr | The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia |
| title_full_unstemmed | The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia |
| title_short | The change in cerebrovascular reactivity between 3T and 7T measured using graded hypercapnia |
| title_sort | change in cerebrovascular reactivity between 3t and 7t measured using graded hypercapnia |
| url | https://eprints.nottingham.ac.uk/1313/ https://eprints.nottingham.ac.uk/1313/ https://eprints.nottingham.ac.uk/1313/ |