Synthesis and biological evaluation of novel compounds as potential modulators of cannabinoid signalling pathways

QR Code

Synthesis and biological evaluation of novel compounds as potential modulators of cannabinoid signalling pathways

Most of the biological effects of cannabis are due to the activation of specific cannabinoid receptors. To date, two such receptors have been discovered and are found predominantly in the central nervous system (the CB1 receptor) or the immune system (the CB2 receptor). Endogenous cannabinoid recept...

Full description

Bibliographic Details
Main Author:	De Bank, Paul A.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2001
Online Access:	https://eprints.nottingham.ac.uk/12414/

Similar Items

Investigating ligand-directed signalling at the cannabinoid receptor 2
by: Hourani, Wafa
Published: (2019)

Investigating the molecular basis of biased signalling at cannabinoid receptors
by: Dennis, Morgan Jane
Published: (2023)

Novel fenofibrate derivatives as cannabinoid receptor ligands
by: Spencer, Sarah Jane
Published: (2011)

Design, synthesis and evaluation of fluorescent CB2 cannabinoid receptor ligands
by: Holt, Christopher James
Published: (2009)

Molecular modelling of the cannabinoid receptors: structure-based design, synthesis and pharmacological evaluation of novel ligands based on the fenofibrate scaffold
by: Loo, Jason S. E.
Published: (2015)

Synthesis and Biological Evaluation of Anti-Parasitic Compounds
by: Gallagher, Ashlee
Published: (2024)

Synthesis and Biological Evaluation of Novel Imidazotetrazines
by: Summers, Helen S
Published: (2019)

Sensory gating and its modulation by cannabinoids: electrophysiological, computational and mathematical analysis
by: Zachariou, Margarita, et al.
Published: (2008)

The synthesis and biological evaluation of novel analogues of isocryptolepine
by: Whittell, Louise Renee'
Published: (2011)

The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors
by: Szabo, M., et al.
Published: (2011)

The effects of cannabinoids on insulin secretion
by: Anderson, Richard L.
Published: (2011)

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer
by: Prasannan, R., et al.
Published: (2012)

Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids
by: Brook, E., et al.
Published: (2019)

Biology of tissue factor pathway inhibitor
by: Wood, J., et al.
Published: (2014)

Synthesis And Activity Studies Of Novel Dispiro Pyrrolidine Compounds As Potential Antimycobacterial Agents
by: Ang , Chee Wei
Published: (2015)

Modulation of cancer signalling pathway(s) in two-stage mouse skin tumorigenesis by annonacin
by: Md Roduan, Mohd Rohaizad, et al.
Published: (2019)

Patterns of synthetic cannabinoid use in Australia
by: Barratt, Monica, et al.
Published: (2012)

Fluorescent cannabinoids: Stratagies towards the synthesis of fluorescently labelled CB2 receptor ligands
by: Yates, Andrew Stephen
Published: (2005)

Synthesis and biological evaluation of novel anti-tumour (E)-styrylsulfonyl methylpyridines
by: Lu, Tiangong
Published: (2014)

Antitumor promoting effect of annonacin mediated via modulation of multiple cancer signaling pathways
by: Abd Hamid @ Abdul Razak, Roslida, et al.
Published: (2018)

Cannabinoid-mediated short-term plasticity in hippocampus
by: Zachariou, Margarita, et al.
Published: (2014)

Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited
by: Constantinescu, Cris S., et al.
Published: (2018)

Synthetic cannabinoids: undesirable alternatives to natural marijuana
by: Palamar, J., et al.
Published: (2016)

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
by: Pieiro, R., et al.
Published: (2011)

Design, synthesis, and biological evaluation of novel arylcarboxamide derivatives as anti-tubercular agents
by: Alsayed, Shahinda SR, et al.
Published: (2020)

Synthesis and biological evaluation of heterocyclic analogues of pregnenolone as novel anti-osteoporotic agents
by: Maurya, S., et al.
Published: (2017)

Synthesis, characterization and biological activity of new azo coumarin compounds
by: Saeed, Yousif Ismael
Published: (2018)

Effect of cannabinoid receptor ligands on microglial cell functions
by: Hassan, Samia
Published: (2013)

Synthetic cannabinoid use among high school seniors
by: Palamar, J., et al.
Published: (2017)

Assessment of GPR18 pairing with putative cannabinoid ligands
by: Abdulrazzaq, Ghayth
Published: (2018)

Structural exploration of cannabinoid receptors using computational methods
by: Murali, Lahari
Published: (2020)

Chromatographic Methods For The Detection Of The Principal Cannabinoid Metabolite In Urine.
by: Vijayan, S., et al.
Published: (1990)

Luteolin, a bioflavonoid inhibits colorectal cancer through modulation of multiple signaling pathways: a review
by: Pandurangan, Ashok Kumar, et al.
Published: (2014)

Modulation of receptor for advanced glycation end products signal transduction pathway as therapeutic option for malaria therapy
by: Chuah, Yaw Kuang
Published: (2015)

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways
by: Moses, Eric
Published: (2018)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
by: Mohd Faudzi, Siti Munirah Mohd Faudzi, et al.
Published: (2015)

Synthesis, characterisation and binding evaluation of new 6-amidinoindole compound as the potential heme binder
by: Noraisyah Abdul Kadir Jilani,, et al.
Published: (2023)

Design, synthesis and biological evaluation of novel nitric oxidedonating protoberberine derivatives as antitumor agents
by: Chen, Jichao, et al.
Published: (2017)

Synthesis and biological evaluation of novel PqsR antagonists to combat Pseudomonas aeruginosa infections
by: Mashabi, Alaa
Published: (2021)

Design, Synthesis and Biological Evaluation of Novel Inhibitors of InhA from Mycobacterium tuberculosis
by: Armstrong, Tom
Published: (2021)