Novel fenofibrate derivatives as cannabinoid receptor ligands
Fenofibrate is a PPARα agonist, used to treat dyslipidemia. Unpublished work that has been previously carried out in our group has identified that fenofibrate also displays affinity for the cannabinoid receptors, CB1 and CB2. A dual receptor ligand, with the PPARα agonist activity of fenofibrate, c...
| Main Author: | Spencer, Sarah Jane |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2011
|
| Online Access: | https://eprints.nottingham.ac.uk/12298/ |
Similar Items
Molecular modelling of the cannabinoid receptors: structure-based design, synthesis and pharmacological evaluation of novel ligands based on the fenofibrate scaffold
by: Loo, Jason S. E.
Published: (2015)
by: Loo, Jason S. E.
Published: (2015)
Effect of cannabinoid receptor ligands on microglial cell functions
by: Hassan, Samia
Published: (2013)
by: Hassan, Samia
Published: (2013)
Investigating ligand-directed signalling at the cannabinoid receptor 2
by: Hourani, Wafa
Published: (2019)
by: Hourani, Wafa
Published: (2019)
Design, synthesis and evaluation of fluorescent CB2 cannabinoid receptor ligands
by: Holt, Christopher James
Published: (2009)
by: Holt, Christopher James
Published: (2009)
Fluorescent cannabinoids: Stratagies towards the synthesis of fluorescently labelled CB2 receptor ligands
by: Yates, Andrew Stephen
Published: (2005)
by: Yates, Andrew Stephen
Published: (2005)
Investigating the molecular basis of biased signalling at cannabinoid receptors
by: Dennis, Morgan Jane
Published: (2023)
by: Dennis, Morgan Jane
Published: (2023)
Assessment of GPR18 pairing with putative cannabinoid ligands
by: Abdulrazzaq, Ghayth
Published: (2018)
by: Abdulrazzaq, Ghayth
Published: (2018)
Structural exploration of cannabinoid receptors using computational methods
by: Murali, Lahari
Published: (2020)
by: Murali, Lahari
Published: (2020)
A study of functional selectivity at the cannabinoid type 1 receptor
by: Priestley, Richard
Published: (2015)
by: Priestley, Richard
Published: (2015)
The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation
by: Pieiro, R., et al.
Published: (2011)
by: Pieiro, R., et al.
Published: (2011)
Preparation And Evaluation Of Fenofibrate-Gelucire 44/14
Solid Dispersions
by: Al-Dhalli, Samer
Published: (2007)
by: Al-Dhalli, Samer
Published: (2007)
Imaging Cannabinoid Receptors: A Brief Collection of Covalent and Fluorescent Probes for CB1 and CB2 Receptors
by: Hamilton, A.J., et al.
Published: (2021)
by: Hamilton, A.J., et al.
Published: (2021)
Design and synthesis of novel P2Y2 receptor ligands
by: Conroy, S.
Published: (2018)
by: Conroy, S.
Published: (2018)
Molecular characterization of cannabinoids and free fatty acid receptors in human and rat skeletal muscle
by: Shermado, Fairouz M.
Published: (2014)
by: Shermado, Fairouz M.
Published: (2014)
Cannabinoid CB1 receptor binding and acetylcholinesterase
inhibitory activity of Sceletium tortuosum L.
by: Lubbe, A., et al.
Published: (2010)
by: Lubbe, A., et al.
Published: (2010)
Cannabinoid CB1 receptor binding and acetylcholinesterase
inhibitory activity of Sceletium tortuosum L.
by: Lubbe, Andrea, et al.
Published: (2010)
by: Lubbe, Andrea, et al.
Published: (2010)
Design, synthesis and pharmacological evaluation of novel fluorescent ligands for the mu-opioid receptor
by: Marshall, William
Published: (2021)
by: Marshall, William
Published: (2021)
The endocannabinoid, anandamide, induces cannabinoid receptor-independent cell death in renal proximal tubule cells
by: Schlosser, Monika, et al.
Published: (2017)
by: Schlosser, Monika, et al.
Published: (2017)
NanoBRET to probe ligand-receptor and receptor-receptor interactions in living cells
by: Carvalheira Alcobia, Diana
Published: (2019)
by: Carvalheira Alcobia, Diana
Published: (2019)
Zerumbone ameliorates neuropathic pain symptoms via
cannabinoid and ppar receptors using in vivo and in
silico models
by: Chia, Jasmine Siew Min, et al.
Published: (2021)
by: Chia, Jasmine Siew Min, et al.
Published: (2021)
Encapsulation of fenofibrate in solid lipid microparticles by central composite face-centred guided by electrospray
by: Azhar, Muhammad Fitri, et al.
Published: (2020)
by: Azhar, Muhammad Fitri, et al.
Published: (2020)
The effects of cannabinoids on insulin secretion
by: Anderson, Richard L.
Published: (2011)
by: Anderson, Richard L.
Published: (2011)
Synthesis and biological evaluation of novel compounds as potential modulators of cannabinoid signalling pathways
by: De Bank, Paul A.
Published: (2001)
by: De Bank, Paul A.
Published: (2001)
Development of novel fluorescent histamine H₁-receptor
antagonists to study ligand-binding kinetics in living cells
by: Stoddart, Leigh A., et al.
Published: (2018)
by: Stoddart, Leigh A., et al.
Published: (2018)
Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor ß (TR-ß) selective ligands
by: Raval, S., et al.
Published: (2008)
by: Raval, S., et al.
Published: (2008)
Potency and species specificity of aryl hydrocarbon receptor ligands
by: Wall, Richard John
Published: (2012)
by: Wall, Richard John
Published: (2012)
Amidoalkylindoles as Potent and Selective Cannabinoid Type 2 Receptor Agonists with in Vivo Efficacy in a Mouse Model of Multiple Sclerosis
by: Shi, Y., et al.
Published: (2017)
by: Shi, Y., et al.
Published: (2017)
Measuring ligand concentration where it matters: Assessing the “micro pharmacokinetic/pharmacodynamics” of adenosine receptor ligands
by: Lochray, Jack
Published: (2022)
by: Lochray, Jack
Published: (2022)
Patterns of synthetic cannabinoid use in Australia
by: Barratt, Monica, et al.
Published: (2012)
by: Barratt, Monica, et al.
Published: (2012)
Chemical and in silico exploration of novel 5-hydroxytryptamine 2A receptor (5-HT2AR) ligands
by: Damerum, Luke
Published: (2024)
by: Damerum, Luke
Published: (2024)
Cell adhesion: stochastic receptor-ligand binding under force
by: Bagdasar, Ovidiu
Published: (2011)
by: Bagdasar, Ovidiu
Published: (2011)
Characterisation of Recombinant
Aryl Hydrocarbon Receptor Ligand Binding Domain
by: Jiang, Tao
Published: (2004)
by: Jiang, Tao
Published: (2004)
Fenofibrate in the management of AbdoMinal aortic anEurysm (FAME): Study protocol for a randomised controlled trial
by: Rowbotham, S., et al.
Published: (2017)
by: Rowbotham, S., et al.
Published: (2017)
Cannabinoid-mediated short-term plasticity in hippocampus
by: Zachariou, Margarita, et al.
Published: (2014)
by: Zachariou, Margarita, et al.
Published: (2014)
Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited
by: Constantinescu, Cris S., et al.
Published: (2018)
by: Constantinescu, Cris S., et al.
Published: (2018)
Synthetic cannabinoids: undesirable alternatives to natural marijuana
by: Palamar, J., et al.
Published: (2016)
by: Palamar, J., et al.
Published: (2016)
Molecular modeling of muscarinic acetylcholine
receptors: Structural basis of ligand-receptor
interactions / Chin Sek Peng
by: Chin, Sek Peng
Published: (2015)
by: Chin, Sek Peng
Published: (2015)
Expression of the Caenorhabditis elegans aryl hydrocarbon receptor ligand binding domain
by: Helaly, Ahmed
Published: (2011)
by: Helaly, Ahmed
Published: (2011)
Recombinant expression of Aryl Hydrocarbon Receptor
for quantitative ligand-binding analysis
by: Fan, MingQi, et al.
Published: (2009)
by: Fan, MingQi, et al.
Published: (2009)
P2X purinergic receptor ligands: recently patented compounds
by: Gunosewoyo, Hendra, et al.
Published: (2010)
by: Gunosewoyo, Hendra, et al.
Published: (2010)
Similar Items
-
Molecular modelling of the cannabinoid receptors: structure-based design, synthesis and pharmacological evaluation of novel ligands based on the fenofibrate scaffold
by: Loo, Jason S. E.
Published: (2015) -
Effect of cannabinoid receptor ligands on microglial cell functions
by: Hassan, Samia
Published: (2013) -
Investigating ligand-directed signalling at the cannabinoid receptor 2
by: Hourani, Wafa
Published: (2019) -
Design, synthesis and evaluation of fluorescent CB2 cannabinoid receptor ligands
by: Holt, Christopher James
Published: (2009) -
Fluorescent cannabinoids: Stratagies towards the synthesis of fluorescently labelled CB2 receptor ligands
by: Yates, Andrew Stephen
Published: (2005)