Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks
Ultra-slow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppressio...
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| Format: | Article |
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American Physical Society
2010
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| Online Access: | https://eprints.nottingham.ac.uk/1227/ |
| _version_ | 1848790564893360128 |
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| author | Hlinka, Jaroslav Coombes, Stephen |
| author_facet | Hlinka, Jaroslav Coombes, Stephen |
| author_sort | Hlinka, Jaroslav |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Ultra-slow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms. |
| first_indexed | 2025-11-14T18:14:38Z |
| format | Article |
| id | nottingham-1227 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:14:38Z |
| publishDate | 2010 |
| publisher | American Physical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-12272020-05-04T20:25:33Z https://eprints.nottingham.ac.uk/1227/ Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks Hlinka, Jaroslav Coombes, Stephen Ultra-slow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms. American Physical Society 2010 Article PeerReviewed Hlinka, Jaroslav and Coombes, Stephen (2010) Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks. Physical Review Letters . ISSN 0031-9007 (In Press) Neural networks Depolarization induced suppression of excitation splay states Morris-Lecar model strong global coupling http://prl.aps.org/ |
| spellingShingle | Neural networks Depolarization induced suppression of excitation splay states Morris-Lecar model strong global coupling Hlinka, Jaroslav Coombes, Stephen Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks |
| title | Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks |
| title_full | Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks |
| title_fullStr | Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks |
| title_full_unstemmed | Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks |
| title_short | Depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks |
| title_sort | depolarization induced suppression of excitation and the emergence of ultra-slow rhythms in neural networks |
| topic | Neural networks Depolarization induced suppression of excitation splay states Morris-Lecar model strong global coupling |
| url | https://eprints.nottingham.ac.uk/1227/ https://eprints.nottingham.ac.uk/1227/ |