Interleukin-4 receptor alpha gene variants and allergic disease
The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described with...
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| Format: | Article |
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2000
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| Online Access: | https://eprints.nottingham.ac.uk/122/ |
| _version_ | 1848790345772433408 |
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| author | Hall, Ian P. |
| author_facet | Hall, Ian P. |
| author_sort | Hall, Ian P. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor alpha (IL-4Ralpha) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Ralpha polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme |
| first_indexed | 2025-11-14T18:11:09Z |
| format | Article |
| id | nottingham-122 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:11:09Z |
| publishDate | 2000 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-1222020-05-04T20:32:58Z https://eprints.nottingham.ac.uk/122/ Interleukin-4 receptor alpha gene variants and allergic disease Hall, Ian P. The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual. A number of polymorphisms have been described within the IL-4 receptor alpha (IL-4Ralpha) gene. In addition polymorphism occurs in the promoter for the IL-4 gene itself. This commentary accompanies a paper by C Ober et al describing the contribution of IL-4Ralpha polymorphism to susceptibility to asthma and atopy in the Hutterite population and other outbred populations collected during the collaborative studies on the genetics of asthma (CSGA) programme 2000 Article PeerReviewed Hall, Ian P. (2000) Interleukin-4 receptor alpha gene variants and allergic disease. Respiratory Research, 1 (1). pp. 6-8. |
| spellingShingle | Hall, Ian P. Interleukin-4 receptor alpha gene variants and allergic disease |
| title | Interleukin-4 receptor alpha gene variants and allergic disease |
| title_full | Interleukin-4 receptor alpha gene variants and allergic disease |
| title_fullStr | Interleukin-4 receptor alpha gene variants and allergic disease |
| title_full_unstemmed | Interleukin-4 receptor alpha gene variants and allergic disease |
| title_short | Interleukin-4 receptor alpha gene variants and allergic disease |
| title_sort | interleukin-4 receptor alpha gene variants and allergic disease |
| url | https://eprints.nottingham.ac.uk/122/ |