The tumour suppressor protein LIMD1 is a novel regulator of HIF1 and the hypoxic response

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The tumour suppressor protein LIMD1 is a novel regulator of HIF1 and the hypoxic response

There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O2 tension. In high O2 tension (normoxia) the PHDs hydroxylate HIFα subunits on 2 conserved proline residues inducing...

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Bibliographic Details
Main Author:	Webb, Thomas M
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2010
Online Access:	https://eprints.nottingham.ac.uk/11280/

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