On the presentation and relevance of laterality: a study of psychosis
A discussion of concepts of lateralization and handedness is followed by an examination of the three-way relationships between lateralization of brain function, level of function, and schizophrenia. It is proposed that conventional examinations of such relationships, using lateralization indices, c...
| Main Author: | |
|---|---|
| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2003
|
| Online Access: | https://eprints.nottingham.ac.uk/11051/ |
| _version_ | 1848791181292470272 |
|---|---|
| author | Leask, Stuart J. |
| author_facet | Leask, Stuart J. |
| author_sort | Leask, Stuart J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | A discussion of concepts of lateralization and handedness is followed by an examination of the three-way relationships between lateralization of brain function, level of function, and schizophrenia. It is proposed that conventional examinations of such relationships, using lateralization indices, can be unenlightening or even misleading, and that alternative approaches are preferable.
Support for this thesis is sought in analyses of data from two UK national birth cohorts. The author's process of gathering data on psychiatric outcomes is presented in detail. Previously-published findings in this data, employing laterality indices, are presented and their shortcomings discussed.
Several alternative approaches to examining the relationships between measures of functional lateralization and level of function are developed, including a novel application of the method of principal curves, and a three-dimensional presentation of function as height over a 'laterality surface'. This latter approach is applied to a number of measures of function in the cohort datasets, including measures of cognitive ability, social success and psychiatric illness, including schizophrenia. The benefits of this method of presentation over previously-published presentations are discussed in the context of several contemporary hypotheses that touch upon the relationships between functional lateralization, cognitive function and schizophrenia. |
| first_indexed | 2025-11-14T18:24:25Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-11051 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T18:24:25Z |
| publishDate | 2003 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-110512025-02-28T11:10:58Z https://eprints.nottingham.ac.uk/11051/ On the presentation and relevance of laterality: a study of psychosis Leask, Stuart J. A discussion of concepts of lateralization and handedness is followed by an examination of the three-way relationships between lateralization of brain function, level of function, and schizophrenia. It is proposed that conventional examinations of such relationships, using lateralization indices, can be unenlightening or even misleading, and that alternative approaches are preferable. Support for this thesis is sought in analyses of data from two UK national birth cohorts. The author's process of gathering data on psychiatric outcomes is presented in detail. Previously-published findings in this data, employing laterality indices, are presented and their shortcomings discussed. Several alternative approaches to examining the relationships between measures of functional lateralization and level of function are developed, including a novel application of the method of principal curves, and a three-dimensional presentation of function as height over a 'laterality surface'. This latter approach is applied to a number of measures of function in the cohort datasets, including measures of cognitive ability, social success and psychiatric illness, including schizophrenia. The benefits of this method of presentation over previously-published presentations are discussed in the context of several contemporary hypotheses that touch upon the relationships between functional lateralization, cognitive function and schizophrenia. 2003 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/11051/1/DMsmallA5.pdf Leask, Stuart J. (2003) On the presentation and relevance of laterality: a study of psychosis. DM thesis, University of Nottingham. |
| spellingShingle | Leask, Stuart J. On the presentation and relevance of laterality: a study of psychosis |
| title | On the presentation and relevance of laterality: a study of psychosis |
| title_full | On the presentation and relevance of laterality: a study of psychosis |
| title_fullStr | On the presentation and relevance of laterality: a study of psychosis |
| title_full_unstemmed | On the presentation and relevance of laterality: a study of psychosis |
| title_short | On the presentation and relevance of laterality: a study of psychosis |
| title_sort | on the presentation and relevance of laterality: a study of psychosis |
| url | https://eprints.nottingham.ac.uk/11051/ |