Optimising targeted antibodies for the treatment of metastatic solid tumours

QR Code

Optimising targeted antibodies for the treatment of metastatic solid tumours

This thesis describes three different strategies employed with the aim of optimising targeted antibodies for the treatment of metastatic solid tumours. Whilst the search for improved predictors of response to anti-EGFR antibodies continues, paired primary and metastatic archived tissue from 32 pati...

Full description

Bibliographic Details
Main Author:	Herbertson, Rebecca A.
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2009
Online Access:	https://eprints.nottingham.ac.uk/10844/

Similar Items

Exploring the ‘Dormancy Activation Switch’ in the tumour microenvironment for metastatic lung cancer: The possible role of MicroRNA
by: Amnani, A., et al.
Published: (2021)

Targeting tumour-astrocyte crosstalk for rational identification of novel therapeutic targets for atypical Teratoid/ Rhabdoid tumours
by: Porter, Harry
Published: (2025)

In vitro assay for investigating potential anti-cancer agents targeting at metastatic level
by: Hashim, Yumi Zuhanis Has-Yun, et al.
Published: (2011)

Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer
by: Ko, S., et al.
Published: (2014)

Isolating novel antibodies against difficult targets using next generation antibody phage display
by: Reader, Rose H
Published: (2019)

Bevacizumab in combination with taxanes for the first-line treatment of metastatic breast cancer
by: Chan, Arlene, et al.
Published: (2010)

Improved orthotopic and metastatic breast cancer models incorporating key elements of the tumour microenvironment enabling patient-relevant drug testing
by: Nicolaou, Niovi
Published: (2015)

The identification of targeting peptides and tumour associated antigens for the treatment and early detection of triple negative breast cancer
by: Wilde, Megan
Published: (2023)

Electrotherapy for the treatment of brain tumours
by: Branter, Joshua
Published: (2020)

Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 and MT1-MMP in tumours
by: Tan, M., et al.
Published: (2010)

An investigation of metastatic colorectal cancer
by: Asiri, Abutaleb
Published: (2018)

A novel approach toward colon cancer treatment involving mucoadhesion and tumour-targeting of curcumin-containing nanoparticles
by: Sabra, Rayan
Published: (2019)

Apoferritin delivery of imidazotetrazine agents for targeted brain tumour therapy
by: Bouzinab, Kaouthar
Published: (2021)

Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: A promising new target for metastatic cancer
by: Alcantara, M., et al.
Published: (2013)

Generation of human monoclonal antibodies: the development of methods to identify and isolate neutralising antibodies targeted to Ebolavirus from peripheral blood
by: Bailey, Graham D.
Published: (2017)

Experimental design of a novel target to isolate HCV monoclonal antibodies
by: Brice, Sophie
Published: (2014)

Repolarisation of the immune-suppressive millieu of the ovarian tumour using targeted therapeutics
by: Khan, Adnan R.
Published: (2012)

Integrating transcriptomics and metabolomics to analyse and target tumour heterogeneity in paediatric ependymoma
by: Pandele, Alina Gabriela
Published: (2024)

The potentiality of Citral in targeting breast cancer multicellular tumour spheroids (MTS)
by: Rusli, Muhammad Ehsan Fitri, et al.
Published: (2022)

Capecitabine and vinorelbine in metastatic breast cancer
by: Chan, Arlene, et al.
Published: (2009)

Water soluble, multifunctional antibody-porphyrin gold nanoparticles for targeted photodynamic therapy
by: Penon, Oriol, et al.
Published: (2017)

Evaluation of a novel antibody to define histone 3.3 G34R mutant brain tumours
by: Haque, Farhana, et al.
Published: (2017)

Cell-Penetrating Antibodies For Targeting Hiv-1 P24 Capsid Protein
by: Teow , Sin Yeang
Published: (2015)

Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein
by: Teow, Sin Yeang
Published: (2015)

Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies
by: Dingjan, T., et al.
Published: (2014)

Mesenchymal stem cell expressing TRAIL as targeted therapy against sensitised tumour
by: Fakiruddin, Kamal Shaik, et al.
Published: (2018)

An investigation of metastatic markers in models of paediatric medulloblastoma
by: Nasir, Aishah
Published: (2017)

Investigating the role of Cten in metastatic colorectal cancer
by: Thorpe, Hannah
Published: (2016)

Metastatic adenocarcinoma of the lung mimicking spinal tuberculosis
by: Zakaria@Mohamad, Zamzuri, et al.
Published: (2011)

In Silico Optimisation Of Domain Antibodies Against HSP16.3 From Mycobacterium Tuberculosis
by: Soong, Jia Xin
Published: (2018)

Metastatic thyroid carcinoma presenting with spinal cord compression.
by: Hassan, H. A., et al.
Published: (2010)

Identification of B-cell epitopes for eliciting neutralizing antibodies against the SARS-CoV-2 spike protein through bioinformatics and monoclonal antibody targeting
by: Lim, Hui Xuan *, et al.
Published: (2022)

Histological analysis of anti-cancer drug loaded, targeted Mn:ZnS quantum dots in metastatic lesions of 4T1 challenged mice
by: Bwatanglang, Ibrahim Birma, et al.
Published: (2017)

Characterization Of Recombinant Antibodies Targeting Hiv-1 Capsid Protein (P24): Towards The Development Of Antibody-Based Therapy Against Hiv/Aids
by: Mualif, Siti Aisyah
Published: (2017)

Polymer coated genetically modified Salmonella enterica serovar agona as tumour targeting agent
by: Taraq Naem Zia, Ubaidah Naim
Published: (2021)

Investigation the role of CD24 in metastatic colorectal cancer
by: Alsulaiman, Abdullah
Published: (2018)

Molecular characterisation of the early metastatic phenotype in colorectal cancer
by: Sculthorpe, Declan
Published: (2024)

Metastatic adenocarcinoma of temporal bone with collet-sicard syndrome
by: Subha, Sethu Thakachy, et al.
Published: (2018)

The current status of checkpoint inhibitors in metastatic bladder cancer
by: Fahmy Ahmed, Omar Ahmed, et al.
Published: (2016)

TILs in metastatic breast cancer—no surprises, but more questions
by: Chan, Arlene
Published: (2017)