Good laboratory practice: preventing introduction of bias at the bench
Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
American Heart Association Inc
2009
|
| Online Access: | https://eprints.nottingham.ac.uk/1075/ |
| _version_ | 1848790535028867072 |
|---|---|
| author | Macleod, Malcolm R. Fisher, Marc O'Collins, Victoria Sena, Emily S. Dirnagl, Ulrich Bath, Philip M.W. Buchan, Alistair van der Worp, H. Bart Traystman, Richard Minematsu, Kazuo Donnan, Geoffrey A. Howells, David W. |
| author_facet | Macleod, Malcolm R. Fisher, Marc O'Collins, Victoria Sena, Emily S. Dirnagl, Ulrich Bath, Philip M.W. Buchan, Alistair van der Worp, H. Bart Traystman, Richard Minematsu, Kazuo Donnan, Geoffrey A. Howells, David W. |
| author_sort | Macleod, Malcolm R. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial
efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.
Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct
and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective
efficacy.
Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal
experiments modeling human stroke. |
| first_indexed | 2025-11-14T18:14:09Z |
| format | Article |
| id | nottingham-1075 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:14:09Z |
| publishDate | 2009 |
| publisher | American Heart Association Inc |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-10752020-05-04T20:26:25Z https://eprints.nottingham.ac.uk/1075/ Good laboratory practice: preventing introduction of bias at the bench Macleod, Malcolm R. Fisher, Marc O'Collins, Victoria Sena, Emily S. Dirnagl, Ulrich Bath, Philip M.W. Buchan, Alistair van der Worp, H. Bart Traystman, Richard Minematsu, Kazuo Donnan, Geoffrey A. Howells, David W. Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Conclusions—Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke. American Heart Association Inc 2009-03 Article PeerReviewed Macleod, Malcolm R., Fisher, Marc, O'Collins, Victoria, Sena, Emily S., Dirnagl, Ulrich, Bath, Philip M.W., Buchan, Alistair, van der Worp, H. Bart, Traystman, Richard, Minematsu, Kazuo, Donnan, Geoffrey A. and Howells, David W. (2009) Good laboratory practice: preventing introduction of bias at the bench. Stroke, 40 (3). e50-e52. ISSN 0039-2499 http://stroke.ahajournals.org/cgi/content/full/40/3/e50 |
| spellingShingle | Macleod, Malcolm R. Fisher, Marc O'Collins, Victoria Sena, Emily S. Dirnagl, Ulrich Bath, Philip M.W. Buchan, Alistair van der Worp, H. Bart Traystman, Richard Minematsu, Kazuo Donnan, Geoffrey A. Howells, David W. Good laboratory practice: preventing introduction of bias at the bench |
| title | Good laboratory practice: preventing introduction of bias at the bench |
| title_full | Good laboratory practice: preventing introduction of bias at the bench |
| title_fullStr | Good laboratory practice: preventing introduction of bias at the bench |
| title_full_unstemmed | Good laboratory practice: preventing introduction of bias at the bench |
| title_short | Good laboratory practice: preventing introduction of bias at the bench |
| title_sort | good laboratory practice: preventing introduction of bias at the bench |
| url | https://eprints.nottingham.ac.uk/1075/ https://eprints.nottingham.ac.uk/1075/ |