2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole is a ligand and shows species-specific partial agonism of the Aryl Hydrocarbon Receptor

2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole is a ligand and shows species-specific partial agonism of the Aryl Hydrocarbon Receptor

2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) and related compounds are a series of anti-cancer candidate pharmaceuticals (Table 1.), that have been shown to activate the AhR. We show that these compounds are high affinity ligands for the rat AhR, but a quantitative assay for their ab...

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Bibliographic Details
Main Authors: Bazzi, Rana, Bradshaw, Tracey D., Rowlands, J. Craig, Stevens, Malcolm F.G., Bell, David Robert
Format: Article
Published: Elsevier 2009
Online Access:https://eprints.nottingham.ac.uk/1069/

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