The a1-Antichymotrypsin -51bp Promoter Polymorphism; Functional Activity and its Role in Alzheimers Disease

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The a1-Antichymotrypsin -51bp Promoter Polymorphism; Functional Activity and its Role in Alzheimers Disease

There is biochemical evidence that the acute phase protein, a1-antichymotrypsin (ACT), is involved in Alzheimer's disease (AD), the most common form of dementia. Inflammation increases the level of ACT in the plasma, and it has been suggested that AD provokes chronic neuroinflammation. One of...

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Bibliographic Details
Main Author:	Ritchie, Alistair Edward
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2004
Subjects:	AD Alzheimer's disease serpin functional assay reporter gene polymorphism promoter genotyping molecular biology functional response EMSA electrophoretic mobility shift assay DNA-binding protein
Online Access:	https://eprints.nottingham.ac.uk/10064/

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