Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata
The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, voafinidine, voalenine and the new bisindole alkaloid, conophyllinine in addition to the prev...
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| Format: | Article |
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2003
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| Online Access: | http://shdl.mmu.edu.my/2609/ |
| _version_ | 1848790102079176704 |
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| author | Kam, Toh-Seok Pang, Huey-Shen Lim, Tuck-Meng |
| author_facet | Kam, Toh-Seok Pang, Huey-Shen Lim, Tuck-Meng |
| author_sort | Kam, Toh-Seok |
| building | MMU Institutional Repository |
| collection | Online Access |
| description | The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, voafinidine, voalenine and the new bisindole alkaloid, conophyllinine in addition to the previously known, biologically active bisindole, conophylline and its congener, conofoline. The structures of the new alkaloids were established by spectroscopic methods. The preparation and characterization of the corresponding quinones of the biologically active bisindoles are also described in relation to a structure-activity study of these compounds with respect to their action in stimulating insulin expression. |
| first_indexed | 2025-11-14T18:07:16Z |
| format | Article |
| id | mmu-2609 |
| institution | Multimedia University |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:07:16Z |
| publishDate | 2003 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | mmu-26092011-08-24T01:34:34Z http://shdl.mmu.edu.my/2609/ Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata Kam, Toh-Seok Pang, Huey-Shen Lim, Tuck-Meng QD Chemistry The ethanol extract of the leaves of Tabernaemontana divaricata (double flower variety) provided a total of 23 alkaloids, including the new aspidosperma alkaloids, taberhanine, voafinine, N-methylvoafinine, voafinidine, voalenine and the new bisindole alkaloid, conophyllinine in addition to the previously known, biologically active bisindole, conophylline and its congener, conofoline. The structures of the new alkaloids were established by spectroscopic methods. The preparation and characterization of the corresponding quinones of the biologically active bisindoles are also described in relation to a structure-activity study of these compounds with respect to their action in stimulating insulin expression. 2003 Article NonPeerReviewed Kam, Toh-Seok and Pang, Huey-Shen and Lim, Tuck-Meng (2003) Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata. Organic & Biomolecular Chemistry, 1 (8). pp. 1292-1297. ISSN 14770520 http://dx.doi.org/10.1039/b301167d doi:10.1039/b301167d doi:10.1039/b301167d |
| spellingShingle | QD Chemistry Kam, Toh-Seok Pang, Huey-Shen Lim, Tuck-Meng Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata |
| title | Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata |
| title_full | Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata |
| title_fullStr | Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata |
| title_full_unstemmed | Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata |
| title_short | Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata |
| title_sort | biologically active indole and bisindole alkaloids from tabernaemontana divaricata |
| topic | QD Chemistry |
| url | http://shdl.mmu.edu.my/2609/ http://shdl.mmu.edu.my/2609/ http://shdl.mmu.edu.my/2609/ |