Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition
Obesity is a chronic disease which has been linked with several metabolic disorders. Till now, there is no ideal pharmacological treatment has been developed for obesity treatment. A nanoparticle or ultrafine particle has attracted the attention of researchers due to its unique physiochemical charac...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
INTI International University
2022
|
| Subjects: | |
| Online Access: | http://eprints.intimal.edu.my/1677/ http://eprints.intimal.edu.my/1677/1/ij2022_35r.pdf http://eprints.intimal.edu.my/1677/2/173 |
| _version_ | 1848766945812283392 |
|---|---|
| author | Cheah, Shi Yan Tey, Lai-Hock Mohammod, Aminuzzaman Akira, Watanabe |
| author_facet | Cheah, Shi Yan Tey, Lai-Hock Mohammod, Aminuzzaman Akira, Watanabe |
| author_sort | Cheah, Shi Yan |
| building | INTI Institutional Repository |
| collection | Online Access |
| description | Obesity is a chronic disease which has been linked with several metabolic disorders. Till now, there is no ideal pharmacological treatment has been developed for obesity treatment. A nanoparticle or ultrafine particle has attracted the attention of researchers due to its unique physiochemical characteristics as a subject tool for physics, chemistry, and biology studies. One of the promising trace elements, chromium, has played a crucial role in the regulation of blood sugar levels and carbohydrates and fats degradation metabolism. Within our project, chromium has been synthesized into chromium oxide nanoparticles (Cr2O3 NPs) using sol-gel method, which has a higher surface area and an oxidizing potential. Chemogenic synthesized Cr2O3 NPs were characterized using UV-Vis Spectrophotometer (UV-Vis), Fourier Transform Infrared Spectroscopy (Ft-IR), Scanning Electron Microscope (SEM), and Energy Dispersive X-Ray Spectroscopy (EDX) confirm the formation and morphology of nanoparticles. Cr2O3 NPs were in spherical shape with an average size of 67.9 nm under SEM analysis and chromium (Cr) (56.7%) and oxygen (O) (43.53%) were analyzed using EDX. Two peaks (272 nm, 368 nm) were shown in UV-Vis characterization and two sharp peaks, 574 cm-1 and 640 cm-1 were present in Ft-IR analysis. Lastly, the pancreatic lipase inhibitory assay, which reduces the absorption of fats into the gastrointestinal system, was appraised on Cr2O3 NPs with 89.48% of inhibition, with half-maximal inhibitory concentration (IC50) at 31.70 ± 2.14 (µg/mL) ± SE. |
| first_indexed | 2025-11-14T11:56:57Z |
| format | Article |
| id | intimal-1677 |
| institution | INTI International University |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T11:59:13Z |
| publishDate | 2022 |
| publisher | INTI International University |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | intimal-16772025-07-24T02:03:27Z http://eprints.intimal.edu.my/1677/ Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition Cheah, Shi Yan Tey, Lai-Hock Mohammod, Aminuzzaman Akira, Watanabe Q Science (General) RM Therapeutics. Pharmacology T Technology (General) Obesity is a chronic disease which has been linked with several metabolic disorders. Till now, there is no ideal pharmacological treatment has been developed for obesity treatment. A nanoparticle or ultrafine particle has attracted the attention of researchers due to its unique physiochemical characteristics as a subject tool for physics, chemistry, and biology studies. One of the promising trace elements, chromium, has played a crucial role in the regulation of blood sugar levels and carbohydrates and fats degradation metabolism. Within our project, chromium has been synthesized into chromium oxide nanoparticles (Cr2O3 NPs) using sol-gel method, which has a higher surface area and an oxidizing potential. Chemogenic synthesized Cr2O3 NPs were characterized using UV-Vis Spectrophotometer (UV-Vis), Fourier Transform Infrared Spectroscopy (Ft-IR), Scanning Electron Microscope (SEM), and Energy Dispersive X-Ray Spectroscopy (EDX) confirm the formation and morphology of nanoparticles. Cr2O3 NPs were in spherical shape with an average size of 67.9 nm under SEM analysis and chromium (Cr) (56.7%) and oxygen (O) (43.53%) were analyzed using EDX. Two peaks (272 nm, 368 nm) were shown in UV-Vis characterization and two sharp peaks, 574 cm-1 and 640 cm-1 were present in Ft-IR analysis. Lastly, the pancreatic lipase inhibitory assay, which reduces the absorption of fats into the gastrointestinal system, was appraised on Cr2O3 NPs with 89.48% of inhibition, with half-maximal inhibitory concentration (IC50) at 31.70 ± 2.14 (µg/mL) ± SE. INTI International University 2022-09 Article PeerReviewed text en cc_by_4 http://eprints.intimal.edu.my/1677/1/ij2022_35r.pdf text en cc_by_4 http://eprints.intimal.edu.my/1677/2/173 Cheah, Shi Yan and Tey, Lai-Hock and Mohammod, Aminuzzaman and Akira, Watanabe (2022) Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition. INTI JOURNAL, 2022 (35). pp. 1-8. ISSN e2600-7320 https://intijournal.intimal.edu.my/intijournal.htm |
| spellingShingle | Q Science (General) RM Therapeutics. Pharmacology T Technology (General) Cheah, Shi Yan Tey, Lai-Hock Mohammod, Aminuzzaman Akira, Watanabe Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition |
| title | Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition |
| title_full | Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition |
| title_fullStr | Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition |
| title_full_unstemmed | Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition |
| title_short | Chemogenic Synthesis of Chromium Oxide Nanoparticles using Sol-Gel Method and its Potential on Pancreatic Lipase Inhibition |
| title_sort | chemogenic synthesis of chromium oxide nanoparticles using sol-gel method and its potential on pancreatic lipase inhibition |
| topic | Q Science (General) RM Therapeutics. Pharmacology T Technology (General) |
| url | http://eprints.intimal.edu.my/1677/ http://eprints.intimal.edu.my/1677/ http://eprints.intimal.edu.my/1677/1/ij2022_35r.pdf http://eprints.intimal.edu.my/1677/2/173 |