Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform
In this paper, we propose an easy-to-implement passive liquid valve (PLV) for the microfluidic compact-disc (CD). This valve can be implemented by introducing venting chambers to control the air flow of the source and destination chambers. The PLV mechanism is based on equalizing the main forces act...
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| Format: | Article |
| Language: | English |
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MDPI AG, Basel, Switzerland
2015
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| Online Access: | http://eprints.intimal.edu.my/15/ http://eprints.intimal.edu.my/15/1/Development%20of%20Passive%20Liquid%20Valve%20%28PLV%29%20Utilizing%20a%20Pressure%20Equilibrium%20Phenomenon%20on%20the%20Centrifugal%20Microfluidic%20Platform.pdf |
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| author | Al-Faqheri, Wisam Ibrahim, Fatimah Tzer, Hwai Gilbert Thio Bahari, Norulain Arof, Hamzah Rothan, Hussin A. Yusof, Rohana Madou, Marc |
| author_facet | Al-Faqheri, Wisam Ibrahim, Fatimah Tzer, Hwai Gilbert Thio Bahari, Norulain Arof, Hamzah Rothan, Hussin A. Yusof, Rohana Madou, Marc |
| author_sort | Al-Faqheri, Wisam |
| building | INTI Institutional Repository |
| collection | Online Access |
| description | In this paper, we propose an easy-to-implement passive liquid valve (PLV) for the microfluidic compact-disc (CD). This valve can be implemented by introducing venting chambers to control the air flow of the source and destination chambers. The PLV mechanism is based on equalizing the main forces acting on the microfluidic CD (i.e., the centrifugal and capillary forces) to control the burst frequency of the source chamber liquid. For a better understanding of the physics behind the proposed PLV, an analytical model is described. Moreover, three parameters that control the effectiveness of the proposed valve, i.e., the liquid height, liquid density, and venting chamber position with respect to the CD center, are tested experimentally. To demonstrate the ability of the proposed PLV valve, microfluidic liquid switching and liquid metering are performed. In addition, a Bradford assay is performed to measure the protein concentration and evaluated in comparison to the benchtop procedure. The result shows that the proposed valve can be implemented in any microfluidic process that requires simplicity and accuracy. Moreover, the developed valve increases the flexibility of the centrifugal CD platform for passive control of the liquid flow without the need for an external force or trigger. |
| first_indexed | 2025-11-14T11:50:09Z |
| format | Article |
| id | intimal-15 |
| institution | INTI International University |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T11:50:09Z |
| publishDate | 2015 |
| publisher | MDPI AG, Basel, Switzerland |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | intimal-152016-09-05T08:28:14Z http://eprints.intimal.edu.my/15/ Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform Al-Faqheri, Wisam Ibrahim, Fatimah Tzer, Hwai Gilbert Thio Bahari, Norulain Arof, Hamzah Rothan, Hussin A. Yusof, Rohana Madou, Marc T Technology (General) In this paper, we propose an easy-to-implement passive liquid valve (PLV) for the microfluidic compact-disc (CD). This valve can be implemented by introducing venting chambers to control the air flow of the source and destination chambers. The PLV mechanism is based on equalizing the main forces acting on the microfluidic CD (i.e., the centrifugal and capillary forces) to control the burst frequency of the source chamber liquid. For a better understanding of the physics behind the proposed PLV, an analytical model is described. Moreover, three parameters that control the effectiveness of the proposed valve, i.e., the liquid height, liquid density, and venting chamber position with respect to the CD center, are tested experimentally. To demonstrate the ability of the proposed PLV valve, microfluidic liquid switching and liquid metering are performed. In addition, a Bradford assay is performed to measure the protein concentration and evaluated in comparison to the benchtop procedure. The result shows that the proposed valve can be implemented in any microfluidic process that requires simplicity and accuracy. Moreover, the developed valve increases the flexibility of the centrifugal CD platform for passive control of the liquid flow without the need for an external force or trigger. MDPI AG, Basel, Switzerland 2015 Article PeerReviewed text en http://eprints.intimal.edu.my/15/1/Development%20of%20Passive%20Liquid%20Valve%20%28PLV%29%20Utilizing%20a%20Pressure%20Equilibrium%20Phenomenon%20on%20the%20Centrifugal%20Microfluidic%20Platform.pdf Al-Faqheri, Wisam and Ibrahim, Fatimah and Tzer, Hwai Gilbert Thio and Bahari, Norulain and Arof, Hamzah and Rothan, Hussin A. and Yusof, Rohana and Madou, Marc (2015) Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform. Sensors, 15 (3). pp. 4658-4676. ISSN 1424-8220 http://www.mdpi.com/journal/sensors 10.3390/s150304658 |
| spellingShingle | T Technology (General) Al-Faqheri, Wisam Ibrahim, Fatimah Tzer, Hwai Gilbert Thio Bahari, Norulain Arof, Hamzah Rothan, Hussin A. Yusof, Rohana Madou, Marc Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title | Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_full | Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_fullStr | Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_full_unstemmed | Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_short | Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform |
| title_sort | development of passive liquid valve (plv) utilizing a pressure equilibrium phenomenon on the centrifugal microfluidic platform |
| topic | T Technology (General) |
| url | http://eprints.intimal.edu.my/15/ http://eprints.intimal.edu.my/15/ http://eprints.intimal.edu.my/15/ http://eprints.intimal.edu.my/15/1/Development%20of%20Passive%20Liquid%20Valve%20%28PLV%29%20Utilizing%20a%20Pressure%20Equilibrium%20Phenomenon%20on%20the%20Centrifugal%20Microfluidic%20Platform.pdf |