Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes
Zinc oxide nanoparticles (ZnO NPs) have been used in the treatment of bacterial infections due to their antibacterial properties. The present study was aimed to explore the antibacterial effects of ZnO NPs on Streptococcus pyogenes. The antibacterial properties were evaluated by investigating the gr...
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Elsevier
2020
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| Online Access: | http://eprints.intimal.edu.my/1401/ |
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| author | Liang, Sharolynne, Xiao Tong Wong*, Ling Shing Lim, Yang Mooi Lee, Poh Foong Sinouvassane, Djearamane |
| author_facet | Liang, Sharolynne, Xiao Tong Wong*, Ling Shing Lim, Yang Mooi Lee, Poh Foong Sinouvassane, Djearamane |
| author_sort | Liang, Sharolynne, Xiao Tong |
| building | INTI Institutional Repository |
| collection | Online Access |
| description | Zinc oxide nanoparticles (ZnO NPs) have been used in the treatment of bacterial infections due to their antibacterial properties. The present study was aimed to explore the antibacterial effects of ZnO NPs on Streptococcus pyogenes. The antibacterial properties were evaluated by investigating the growth inhibition and oxidative stress effects of ZnO NPs on S. pyogenes. The bacterial growth inhibition was determined through the percentage of reduction in the turbidity of bacterial suspension and bacterial colony upon treating with ZnO NPs, while the oxidative stress of ZnO NPs on bacterial cells were assessed by measuring the levels of reactive oxygen species (ROS) and lipid peroxidation. The results showed the dose dependent and significant (p < 0.05) growth inhibition and oxidative stress effects on S. pyogenes for 10 to 100 μg/mL ZnO NPs at 24 h. Fourier-transform infrared spectrometry (FTIR) analysis confirmed the binding of ZnO NPs to polypeptides and glycogen from the bacterial cell wall. Further, the scanning electron microscopy (SEM) results showed the attachment of ZnO NPs to bacterial cell wall and the resultant cell wall disruption and cell damage. The study results confirmed the antimicrobial effects of ZnO NPs on S. pyogenes. |
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| format | Article |
| id | intimal-1401 |
| institution | INTI International University |
| institution_category | Local University |
| last_indexed | 2025-11-14T11:55:45Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
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| spelling | intimal-14012020-09-01T03:41:05Z http://eprints.intimal.edu.my/1401/ Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes Liang, Sharolynne, Xiao Tong Wong*, Ling Shing Lim, Yang Mooi Lee, Poh Foong Sinouvassane, Djearamane Q Science (General) QD Chemistry TP Chemical technology Zinc oxide nanoparticles (ZnO NPs) have been used in the treatment of bacterial infections due to their antibacterial properties. The present study was aimed to explore the antibacterial effects of ZnO NPs on Streptococcus pyogenes. The antibacterial properties were evaluated by investigating the growth inhibition and oxidative stress effects of ZnO NPs on S. pyogenes. The bacterial growth inhibition was determined through the percentage of reduction in the turbidity of bacterial suspension and bacterial colony upon treating with ZnO NPs, while the oxidative stress of ZnO NPs on bacterial cells were assessed by measuring the levels of reactive oxygen species (ROS) and lipid peroxidation. The results showed the dose dependent and significant (p < 0.05) growth inhibition and oxidative stress effects on S. pyogenes for 10 to 100 μg/mL ZnO NPs at 24 h. Fourier-transform infrared spectrometry (FTIR) analysis confirmed the binding of ZnO NPs to polypeptides and glycogen from the bacterial cell wall. Further, the scanning electron microscopy (SEM) results showed the attachment of ZnO NPs to bacterial cell wall and the resultant cell wall disruption and cell damage. The study results confirmed the antimicrobial effects of ZnO NPs on S. pyogenes. Elsevier 2020-10-01 Article PeerReviewed Liang, Sharolynne, Xiao Tong and Wong*, Ling Shing and Lim, Yang Mooi and Lee, Poh Foong and Sinouvassane, Djearamane (2020) Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes. South African Journal of Chemical Engineering, 34. pp. 63-71. ISSN 1026-9185 https://doi.org/10.1016/j.sajce.2020.05.009 |
| spellingShingle | Q Science (General) QD Chemistry TP Chemical technology Liang, Sharolynne, Xiao Tong Wong*, Ling Shing Lim, Yang Mooi Lee, Poh Foong Sinouvassane, Djearamane Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes |
| title | Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes |
| title_full | Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes |
| title_fullStr | Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes |
| title_full_unstemmed | Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes |
| title_short | Effects of Zinc Oxide nanoparticles on Streptococcus pyogenes |
| title_sort | effects of zinc oxide nanoparticles on streptococcus pyogenes |
| topic | Q Science (General) QD Chemistry TP Chemical technology |
| url | http://eprints.intimal.edu.my/1401/ http://eprints.intimal.edu.my/1401/ |