| Summary: | Dispersive liquid-liquid microextraction (DLLME) is a novel sample preparation technique that has higher level of
extraction efficiency by means of relying on micro volumes of solvents. It has gained considerable attention from
researchers owing to several advantages such as its simplicity, shorter extraction time, lower cost and higher
enrichment factor. In conventional DLLME, chlorinated solvents are widely used as the extraction solvents.
Notwithstanding, most of these solvents are reportedly toxic and environmentally-unfriendly. Many related studies
in recent years have focused on the use of non-toxic or low toxic extraction solvents and better practical procedures,
which have helped improve the extraction efficiency. The aim of this review is to discuss the development of low
toxic extraction solvent used recently in the DLLME. The possible improvement of extraction solvent from the
green analytical chemistry perspectives is also discussed.
Keywords: extraction solvents, dispersive liquid-liquid microextraction, green analytical chemistry
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