Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats
Introduction: Reduced cerebral blood fl ow is associated with neurodegenerative disorders and dementia, in particular. Experimental evidence has demonstrated the initiating role of chronic cerebral hypoperfusion in neuronal damage to the hippocampus, the cerebral cortex, the white matter areas and...
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| Language: | English |
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Faculty of Medicine, International Islamic University Malaysia
2011
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| Online Access: | http://irep.iium.edu.my/9981/ http://irep.iium.edu.my/9981/1/download.pdf |
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| author | Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Mustafa Mahmoud, Mohammed Imad Al-Deen |
| author_facet | Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Mustafa Mahmoud, Mohammed Imad Al-Deen |
| author_sort | Saxena, Anil Kumar |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Reduced cerebral blood fl ow is associated with neurodegenerative disorders and dementia, in particular. Experimental evidence has demonstrated the initiating role of chronic cerebral hypoperfusion in
neuronal damage to the hippocampus, the cerebral cortex, the white matter areas and the visual system.
Permanent, bilateral occlusion of the common carotid arteries of rats (two vessel occlusion - 2VO) has been
introduced for the reproduction of chronic cerebral hypoperfusion as it occurs in Alzheimer’s disease and human
aging. Increased generation of free radicals through lipid peroxidation can damage neuronal cell membrane.
Markers of lipid peroxidation have been found to be elevated in brain tissues and body fluids in neurodegenerative diseases, including Alzheimer’s disease, Parkinson disease and amyotrophic lateral sclerosis. Materials and Methods: Malondialdehyde (MDA), final product of lipid peroxidation, was estimated by thiobarbituric
acid-reactive substances (TBARS) assay kit at eight weeks after induction of 2VO in the rats and control group.
Results: Our study revealed a highly signifi cant (p<0.001) increase in the mean MDA concentration (12.296 ± 1.113 ìM) in 2VO rats as compared to the control group (5.286 ± 0.363 ìM) rats. Conclusion: Therapeutic strategies to modulate lipid peroxidation early throughout the course of the disease may be promising in slowing or possibly preventing neurodegenerative disorders. |
| first_indexed | 2025-11-14T14:42:13Z |
| format | Article |
| id | iium-9981 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:42:13Z |
| publishDate | 2011 |
| publisher | Faculty of Medicine, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-99812013-04-11T03:17:38Z http://irep.iium.edu.my/9981/ Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Mustafa Mahmoud, Mohammed Imad Al-Deen RC321 Neuroscience. Biological psychiatry. Neuropsychiatry Introduction: Reduced cerebral blood fl ow is associated with neurodegenerative disorders and dementia, in particular. Experimental evidence has demonstrated the initiating role of chronic cerebral hypoperfusion in neuronal damage to the hippocampus, the cerebral cortex, the white matter areas and the visual system. Permanent, bilateral occlusion of the common carotid arteries of rats (two vessel occlusion - 2VO) has been introduced for the reproduction of chronic cerebral hypoperfusion as it occurs in Alzheimer’s disease and human aging. Increased generation of free radicals through lipid peroxidation can damage neuronal cell membrane. Markers of lipid peroxidation have been found to be elevated in brain tissues and body fluids in neurodegenerative diseases, including Alzheimer’s disease, Parkinson disease and amyotrophic lateral sclerosis. Materials and Methods: Malondialdehyde (MDA), final product of lipid peroxidation, was estimated by thiobarbituric acid-reactive substances (TBARS) assay kit at eight weeks after induction of 2VO in the rats and control group. Results: Our study revealed a highly signifi cant (p<0.001) increase in the mean MDA concentration (12.296 ± 1.113 ìM) in 2VO rats as compared to the control group (5.286 ± 0.363 ìM) rats. Conclusion: Therapeutic strategies to modulate lipid peroxidation early throughout the course of the disease may be promising in slowing or possibly preventing neurodegenerative disorders. Faculty of Medicine, International Islamic University Malaysia 2011-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/9981/1/download.pdf Saxena, Anil Kumar and Abdul Majeed, Saif Saad and Oothuman, Pakeer and Mustafa Mahmoud, Mohammed Imad Al-Deen (2011) Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats. International Medical Journal Malaysia, 10 (2). pp. 3-6. ISSN 1823-4631 http://www.e-imj.com/ |
| spellingShingle | RC321 Neuroscience. Biological psychiatry. Neuropsychiatry Saxena, Anil Kumar Abdul Majeed, Saif Saad Oothuman, Pakeer Mustafa Mahmoud, Mohammed Imad Al-Deen Lipid peroxidation in chronic cerebral hypoperfusion- induced neurodegeneration in rats |
| title | Lipid peroxidation in chronic cerebral hypoperfusion-
induced neurodegeneration in rats |
| title_full | Lipid peroxidation in chronic cerebral hypoperfusion-
induced neurodegeneration in rats |
| title_fullStr | Lipid peroxidation in chronic cerebral hypoperfusion-
induced neurodegeneration in rats |
| title_full_unstemmed | Lipid peroxidation in chronic cerebral hypoperfusion-
induced neurodegeneration in rats |
| title_short | Lipid peroxidation in chronic cerebral hypoperfusion-
induced neurodegeneration in rats |
| title_sort | lipid peroxidation in chronic cerebral hypoperfusion-
induced neurodegeneration in rats |
| topic | RC321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| url | http://irep.iium.edu.my/9981/ http://irep.iium.edu.my/9981/ http://irep.iium.edu.my/9981/1/download.pdf |