Potential bioactivities of -mangostin from garcinia malaccensis Hk.f
Guttiferae family is well-known to have a wide range of phytochemical constituents and bioactivities. A phytochemical investigation of Garcinia malaccensis lead isolation of -mangostin, -mangostin and a triterpenoid. α-Mangostin, a xanthone has a lot of health benefits. Many studies have been repo...
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| Format: | Proceeding Paper |
| Language: | English |
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2011
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| Online Access: | http://irep.iium.edu.my/8796/ http://irep.iium.edu.my/8796/1/IRIE11-Registration_form-M.Taher-Mangostin-2.pdf |
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| author | Bakhtiar, M. Taher Darnis, Deny Susanti Solachuddin Jauhari, Arief Ichwan Ahmad Zohri, Farah Syahidah Nakazibwe, Sauba |
| author_facet | Bakhtiar, M. Taher Darnis, Deny Susanti Solachuddin Jauhari, Arief Ichwan Ahmad Zohri, Farah Syahidah Nakazibwe, Sauba |
| author_sort | Bakhtiar, M. Taher |
| building | IIUM Repository |
| collection | Online Access |
| description | Guttiferae family is well-known to have a wide range of phytochemical constituents and bioactivities. A phytochemical investigation of Garcinia malaccensis lead isolation of -mangostin, -mangostin and a triterpenoid. α-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of α-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of α-mangostin. Its structural determination was done based on its spectroscopic analysis. α-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S. aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MIC) value was 0.025 mg/mL and minimum bactericidal concentration (MBC) value was 0.1 mg/mL, indicated that α-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of α-mangostin. In FTC method, α-mangostin was proved to be a good lipid peroxidation inhibitor, whereas in DPPH free radical scavenging activity method, it has very weak scavenging effects on free radicals. In antiproliferative assay, -mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20 µg/mL. This study can form a foundation for future studies in investigating of biological activities of α-mangostin and developing the natural abundant in improving a healthy community. |
| first_indexed | 2025-11-14T14:40:03Z |
| format | Proceeding Paper |
| id | iium-8796 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:40:03Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-87962014-12-09T01:30:29Z http://irep.iium.edu.my/8796/ Potential bioactivities of -mangostin from garcinia malaccensis Hk.f Bakhtiar, M. Taher Darnis, Deny Susanti Solachuddin Jauhari, Arief Ichwan Ahmad Zohri, Farah Syahidah Nakazibwe, Sauba RS Pharmacy and materia medica Guttiferae family is well-known to have a wide range of phytochemical constituents and bioactivities. A phytochemical investigation of Garcinia malaccensis lead isolation of -mangostin, -mangostin and a triterpenoid. α-Mangostin, a xanthone has a lot of health benefits. Many studies have been reported to investigate the biological activities of α-mangostin. The present study was carried out to evaluate the antimicrobial, antioxidant and anticancer activities of α-mangostin. Its structural determination was done based on its spectroscopic analysis. α-Mangostin was tested for antimicrobial sensitivity via disc diffusion method against 4 bacteria. Results showed that S. aureus culture formed a clear inhibition zone. The diameter of zone of inhibition observed was 8 mm and minimum inhibition concentration (MIC) value was 0.025 mg/mL and minimum bactericidal concentration (MBC) value was 0.1 mg/mL, indicated that α-mangostin is a bacteriostatic and bactericidal agent which correlates to presence of hydroxyl group in its structure. In antioxidant properties tests, dot-blot DPPH staining showed a positive antioxidant activity of α-mangostin. In FTC method, α-mangostin was proved to be a good lipid peroxidation inhibitor, whereas in DPPH free radical scavenging activity method, it has very weak scavenging effects on free radicals. In antiproliferative assay, -mangostin exhibited activity against K562 and showed different activity against HSC3 and H1299 cell lines. Against K562, it exerted the value of IC50 20 µg/mL. This study can form a foundation for future studies in investigating of biological activities of α-mangostin and developing the natural abundant in improving a healthy community. 2011-02 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/8796/1/IRIE11-Registration_form-M.Taher-Mangostin-2.pdf Bakhtiar, M. Taher and Darnis, Deny Susanti and Solachuddin Jauhari, Arief Ichwan and Ahmad Zohri, Farah Syahidah and Nakazibwe, Sauba (2011) Potential bioactivities of -mangostin from garcinia malaccensis Hk.f. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2011, 9-10 February 2011, Cultural Activity Centre (CAC) and KAED Gallery IIUM. http://www.iium.edu.my/irie/11/ |
| spellingShingle | RS Pharmacy and materia medica Bakhtiar, M. Taher Darnis, Deny Susanti Solachuddin Jauhari, Arief Ichwan Ahmad Zohri, Farah Syahidah Nakazibwe, Sauba Potential bioactivities of -mangostin from garcinia malaccensis Hk.f |
| title | Potential bioactivities of -mangostin from garcinia malaccensis Hk.f |
| title_full | Potential bioactivities of -mangostin from garcinia malaccensis Hk.f |
| title_fullStr | Potential bioactivities of -mangostin from garcinia malaccensis Hk.f |
| title_full_unstemmed | Potential bioactivities of -mangostin from garcinia malaccensis Hk.f |
| title_short | Potential bioactivities of -mangostin from garcinia malaccensis Hk.f |
| title_sort | potential bioactivities of -mangostin from garcinia malaccensis hk.f |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/8796/ http://irep.iium.edu.my/8796/ http://irep.iium.edu.my/8796/1/IRIE11-Registration_form-M.Taher-Mangostin-2.pdf |