Development of alpha mangostin-PLGA nanoparticles as an anticancer agent
α-Mangostin, a xanthone which was isolated from Garcinia malaccensis has been documented to exhibit anticancer effects against many cancerous cell lines. Due its high cytotoxicity, this study had attempted to encapsulate the α-mangostin into biodegradable PLGA copolymer using colloidal-extraction so...
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2011
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| Online Access: | http://irep.iium.edu.my/8785/ http://irep.iium.edu.my/8785/1/Abstract_Dr._Taher-IHCI2011_8785.pdf http://irep.iium.edu.my/8785/3/mangosteen-IHCI_poster_after_correct_.pdf |
| _version_ | 1848777062320439296 |
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| author | Aimen, Abdo Mohamed, Farahidah Bakhtiar, M. Taher |
| author_facet | Aimen, Abdo Mohamed, Farahidah Bakhtiar, M. Taher |
| author_sort | Aimen, Abdo |
| building | IIUM Repository |
| collection | Online Access |
| description | α-Mangostin, a xanthone which was isolated from Garcinia malaccensis has been documented to exhibit anticancer effects against many cancerous cell lines. Due its high cytotoxicity, this study had attempted to encapsulate the α-mangostin into biodegradable PLGA copolymer using colloidal-extraction solvent evaporation method. Different emulsification process had been investigated. The resultant nanoparticles were characterized for their size distribution and external morphology by laser diffractometry and scanning electron microscope (SEM), respectively. The concentration of entrapped α-Mangostin was determined by HPLC. Our data demonstrated that the encapsulation efficiency was affected by the type of emulsification process. The in vitro anti-cancer activity of α-Mangostin-PLGA nanoparticles was evaluated using lung cancer cell line (A549) and was compared to the free α-Mangostin. Our data revealed that the PLGA nanoparticles loaded with α-Mangostin showed lower cytotoxic effect compared to free α-Mangostin. To conclude, PLGA nanoparticles may be used as a promising micro-carrier system to deliver α-Mangostin for passive targeting to tumors.
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| first_indexed | 2025-11-14T14:40:01Z |
| format | Proceeding Paper |
| id | iium-8785 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T14:40:01Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-87852014-12-09T01:13:41Z http://irep.iium.edu.my/8785/ Development of alpha mangostin-PLGA nanoparticles as an anticancer agent Aimen, Abdo Mohamed, Farahidah Bakhtiar, M. Taher RM300 Drugs and their action α-Mangostin, a xanthone which was isolated from Garcinia malaccensis has been documented to exhibit anticancer effects against many cancerous cell lines. Due its high cytotoxicity, this study had attempted to encapsulate the α-mangostin into biodegradable PLGA copolymer using colloidal-extraction solvent evaporation method. Different emulsification process had been investigated. The resultant nanoparticles were characterized for their size distribution and external morphology by laser diffractometry and scanning electron microscope (SEM), respectively. The concentration of entrapped α-Mangostin was determined by HPLC. Our data demonstrated that the encapsulation efficiency was affected by the type of emulsification process. The in vitro anti-cancer activity of α-Mangostin-PLGA nanoparticles was evaluated using lung cancer cell line (A549) and was compared to the free α-Mangostin. Our data revealed that the PLGA nanoparticles loaded with α-Mangostin showed lower cytotoxic effect compared to free α-Mangostin. To conclude, PLGA nanoparticles may be used as a promising micro-carrier system to deliver α-Mangostin for passive targeting to tumors. 2011-12-07 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/8785/1/Abstract_Dr._Taher-IHCI2011_8785.pdf application/pdf en http://irep.iium.edu.my/8785/3/mangosteen-IHCI_poster_after_correct_.pdf Aimen, Abdo and Mohamed, Farahidah and Bakhtiar, M. Taher (2011) Development of alpha mangostin-PLGA nanoparticles as an anticancer agent. In: International Health Conference IIUM (IHCI 2011), 7-8 December 2011, Vistana Hotel, Kuantan. (Unpublished) |
| spellingShingle | RM300 Drugs and their action Aimen, Abdo Mohamed, Farahidah Bakhtiar, M. Taher Development of alpha mangostin-PLGA nanoparticles as an anticancer agent |
| title | Development of alpha mangostin-PLGA nanoparticles as an anticancer agent |
| title_full | Development of alpha mangostin-PLGA nanoparticles as an anticancer agent |
| title_fullStr | Development of alpha mangostin-PLGA nanoparticles as an anticancer agent |
| title_full_unstemmed | Development of alpha mangostin-PLGA nanoparticles as an anticancer agent |
| title_short | Development of alpha mangostin-PLGA nanoparticles as an anticancer agent |
| title_sort | development of alpha mangostin-plga nanoparticles as an anticancer agent |
| topic | RM300 Drugs and their action |
| url | http://irep.iium.edu.my/8785/ http://irep.iium.edu.my/8785/1/Abstract_Dr._Taher-IHCI2011_8785.pdf http://irep.iium.edu.my/8785/3/mangosteen-IHCI_poster_after_correct_.pdf |