Potentiation of testicular cytotoxicity by the alkyltransferase inhibitor O6 benzylguanine and the 5-fluorouracil/N-(2-chloroethyl)-N-nitrosourea molecular combination, B.4152

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Potentiation of testicular cytotoxicity by the alkyltransferase inhibitor O6 benzylguanine and the 5-fluorouracil/N-(2-chloroethyl)-N-nitrosourea molecular combination, B.4152

Alkylating agents are a group of compounds that have a cytotoxic effect due to their ability to form adducts with DNA. Cells possess the ability to repair this damage via an enzyme, O6-alkylguanine-DNA alkyltransferase (AGT). To study the effect of inhibiting this repair mechanism upon testicular cy...

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Bibliographic Details
Main Authors:	Thompson, Michael J., Abdul Rahman, Suzanah, Baker, Theresa G., Bibby, Michael Charles
Format:	Article
Language:	English
Published:	Elsevier 1996
Subjects:	RA1190 Toxicology RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/8409/ http://irep.iium.edu.my/8409/1/Reprod_Tox_1996_Suzanah.pdf

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