Management of refractory heartburn: are we convinced that surgery is better than medical treatment?
In a nutshell, this was a single centre, randomised-controlled trial comparing surgical vs medical modality in treating protonpump inhibitor (PPI)-refractory heartburn; a common condition where optimal treatment approach is not known. All patients referred to the Veterans Affairs gastroenterology cl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English |
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Royal College of Physicians of Edinburgh
2020
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| Online Access: | http://irep.iium.edu.my/82678/ http://irep.iium.edu.my/82678/1/82678_Management%20of%20refractory%20heartburn_ft.pdf http://irep.iium.edu.my/82678/2/82678_Management%20of%20refractory%20heartburn_scopus.pdf |
| _version_ | 1848789347097116672 |
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| author | Md Jalil, Muhammad Ateeq Wong, Zhiqin Raja Ali, Raja Affendi Lee, Yeong Yeh |
| author_facet | Md Jalil, Muhammad Ateeq Wong, Zhiqin Raja Ali, Raja Affendi Lee, Yeong Yeh |
| author_sort | Md Jalil, Muhammad Ateeq |
| building | IIUM Repository |
| collection | Online Access |
| description | In a nutshell, this was a single centre, randomised-controlled trial comparing surgical vs medical modality in treating protonpump inhibitor (PPI)-refractory heartburn; a common condition where optimal treatment approach is not known. All patients referred to the Veterans Affairs gastroenterology clinics for refractory heartburn were screened. Eligible patients would complete the gastro-oesophageal refl ux disease (GORD) – Health Related Quality of Life (GORD-HRQL) questionnaire followed by 2-week trial of omeprazole at a dose of 20 mg twice daily, after which the GORD-HRQL was repeated. Patients who did not show improvement (i.e. decrease of >50% in the initial GORD-HRQL score) then underwent endoscopy with biopsies from the lower oesophagus, but also oesophageal manometry and intraluminal impedance– pH monitoring while continuing omeprazole at the same dose and frequency. Patients with severe refl ux oesophagitis, nonGORD endoscopic abnormalities, oeosinophilic oesophagitis, achalasia or absent contractility were excluded. Other patientreported outcomes included depression, anxiety and health function. |
| first_indexed | 2025-11-14T17:55:16Z |
| format | Article |
| id | iium-82678 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:55:16Z |
| publishDate | 2020 |
| publisher | Royal College of Physicians of Edinburgh |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-826782020-09-07T01:59:15Z http://irep.iium.edu.my/82678/ Management of refractory heartburn: are we convinced that surgery is better than medical treatment? Md Jalil, Muhammad Ateeq Wong, Zhiqin Raja Ali, Raja Affendi Lee, Yeong Yeh R Medicine (General) RD Surgery In a nutshell, this was a single centre, randomised-controlled trial comparing surgical vs medical modality in treating protonpump inhibitor (PPI)-refractory heartburn; a common condition where optimal treatment approach is not known. All patients referred to the Veterans Affairs gastroenterology clinics for refractory heartburn were screened. Eligible patients would complete the gastro-oesophageal refl ux disease (GORD) – Health Related Quality of Life (GORD-HRQL) questionnaire followed by 2-week trial of omeprazole at a dose of 20 mg twice daily, after which the GORD-HRQL was repeated. Patients who did not show improvement (i.e. decrease of >50% in the initial GORD-HRQL score) then underwent endoscopy with biopsies from the lower oesophagus, but also oesophageal manometry and intraluminal impedance– pH monitoring while continuing omeprazole at the same dose and frequency. Patients with severe refl ux oesophagitis, nonGORD endoscopic abnormalities, oeosinophilic oesophagitis, achalasia or absent contractility were excluded. Other patientreported outcomes included depression, anxiety and health function. Royal College of Physicians of Edinburgh 2020 Article PeerReviewed application/pdf en http://irep.iium.edu.my/82678/1/82678_Management%20of%20refractory%20heartburn_ft.pdf application/pdf en http://irep.iium.edu.my/82678/2/82678_Management%20of%20refractory%20heartburn_scopus.pdf Md Jalil, Muhammad Ateeq and Wong, Zhiqin and Raja Ali, Raja Affendi and Lee, Yeong Yeh (2020) Management of refractory heartburn: are we convinced that surgery is better than medical treatment? Journal of the Royal College of Physicians of Edinburgh, 50 (1). pp. 51-53. ISSN 1478-2715 https://www.rcpe.ac.uk/college/journal/volume-50-issue-1-2020-2 10.4997/JRCPE.2020.114 |
| spellingShingle | R Medicine (General) RD Surgery Md Jalil, Muhammad Ateeq Wong, Zhiqin Raja Ali, Raja Affendi Lee, Yeong Yeh Management of refractory heartburn: are we convinced that surgery is better than medical treatment? |
| title | Management of refractory heartburn: are we convinced that surgery is better than medical treatment? |
| title_full | Management of refractory heartburn: are we convinced that surgery is better than medical treatment? |
| title_fullStr | Management of refractory heartburn: are we convinced that surgery is better than medical treatment? |
| title_full_unstemmed | Management of refractory heartburn: are we convinced that surgery is better than medical treatment? |
| title_short | Management of refractory heartburn: are we convinced that surgery is better than medical treatment? |
| title_sort | management of refractory heartburn: are we convinced that surgery is better than medical treatment? |
| topic | R Medicine (General) RD Surgery |
| url | http://irep.iium.edu.my/82678/ http://irep.iium.edu.my/82678/ http://irep.iium.edu.my/82678/ http://irep.iium.edu.my/82678/1/82678_Management%20of%20refractory%20heartburn_ft.pdf http://irep.iium.edu.my/82678/2/82678_Management%20of%20refractory%20heartburn_scopus.pdf |