Synthesis and characterization of orotic acid loaded chitosan inclusion complex
The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/ CS was carried out using fourier transform infrared spectro...
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| Format: | Article |
| Language: | English English |
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International Journal of Drug Delivery Technology
2020
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| Online Access: | http://irep.iium.edu.my/82571/ http://irep.iium.edu.my/82571/7/82571_Synthesis%20and%20characterization%20of%20orotic%20acid%20loaded%20chitosan%20inclusion%20complex.pdf http://irep.iium.edu.my/82571/13/82571_Synthesis%20and%20characterization.pdf |
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| author | Hassani, Abdelkader Azad, Abul Kalam Enezei, Hamid H. Hussain, Siti A. Helal Uddin, A.B.M. |
| author_facet | Hassani, Abdelkader Azad, Abul Kalam Enezei, Hamid H. Hussain, Siti A. Helal Uddin, A.B.M. |
| author_sort | Hassani, Abdelkader |
| building | IIUM Repository |
| collection | Online Access |
| description | The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS).
The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/
CS was carried out using fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), differential scanning
calorimetry (DSC), zeta sizer, and transmission electron microscopy (TEM). Furthermore, the size of OA/CS ranged between
58 nm and 200 nm, and the zeta potential was 30 mV. Thus, this study indicates that OA/CS has a promising future to develop
a carrier for drug delivery systems further.
Keywords: Chitosan, Drug delivery, Inclusion complex, Orotic acid, Synthesis.
International Journal of Drug Delivery Technology (2020); DOI: 10.25258/ijddt.10.1.1
How to cite this article: Hassani A, Azad AK, Enezei HH, Hussain SA, Helal Uddin ABM. Synthesis and Characterization
of Orotic Acid Loaded Chitosan Inclusion Complex. International Journal of Drug Delivery Technology. 2020; 10(1): 1-4. |
| first_indexed | 2025-11-14T17:54:53Z |
| format | Article |
| id | iium-82571 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:54:53Z |
| publishDate | 2020 |
| publisher | International Journal of Drug Delivery Technology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-825712022-11-07T02:25:05Z http://irep.iium.edu.my/82571/ Synthesis and characterization of orotic acid loaded chitosan inclusion complex Hassani, Abdelkader Azad, Abul Kalam Enezei, Hamid H. Hussain, Siti A. Helal Uddin, A.B.M. QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). The OA/CS inclusion complex was synthesized using the freeze-drying technique. The characterization of inclusion OA/ CS was carried out using fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), zeta sizer, and transmission electron microscopy (TEM). Furthermore, the size of OA/CS ranged between 58 nm and 200 nm, and the zeta potential was 30 mV. Thus, this study indicates that OA/CS has a promising future to develop a carrier for drug delivery systems further. Keywords: Chitosan, Drug delivery, Inclusion complex, Orotic acid, Synthesis. International Journal of Drug Delivery Technology (2020); DOI: 10.25258/ijddt.10.1.1 How to cite this article: Hassani A, Azad AK, Enezei HH, Hussain SA, Helal Uddin ABM. Synthesis and Characterization of Orotic Acid Loaded Chitosan Inclusion Complex. International Journal of Drug Delivery Technology. 2020; 10(1): 1-4. International Journal of Drug Delivery Technology 2020-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/82571/7/82571_Synthesis%20and%20characterization%20of%20orotic%20acid%20loaded%20chitosan%20inclusion%20complex.pdf application/pdf en http://irep.iium.edu.my/82571/13/82571_Synthesis%20and%20characterization.pdf Hassani, Abdelkader and Azad, Abul Kalam and Enezei, Hamid H. and Hussain, Siti A. and Helal Uddin, A.B.M. (2020) Synthesis and characterization of orotic acid loaded chitosan inclusion complex. International Journal of Drug Delivery Technology, 10 (1). pp. 1-4. ISSN 0975-4415 https://ijddt.com/volume10issue1/ |
| spellingShingle | QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Hassani, Abdelkader Azad, Abul Kalam Enezei, Hamid H. Hussain, Siti A. Helal Uddin, A.B.M. Synthesis and characterization of orotic acid loaded chitosan inclusion complex |
| title | Synthesis and characterization of orotic acid loaded chitosan inclusion
complex |
| title_full | Synthesis and characterization of orotic acid loaded chitosan inclusion
complex |
| title_fullStr | Synthesis and characterization of orotic acid loaded chitosan inclusion
complex |
| title_full_unstemmed | Synthesis and characterization of orotic acid loaded chitosan inclusion
complex |
| title_short | Synthesis and characterization of orotic acid loaded chitosan inclusion
complex |
| title_sort | synthesis and characterization of orotic acid loaded chitosan inclusion
complex |
| topic | QD Chemistry RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/82571/ http://irep.iium.edu.my/82571/ http://irep.iium.edu.my/82571/7/82571_Synthesis%20and%20characterization%20of%20orotic%20acid%20loaded%20chitosan%20inclusion%20complex.pdf http://irep.iium.edu.my/82571/13/82571_Synthesis%20and%20characterization.pdf |