MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance
This paper presents the use of a commercial quartz crystal microbalance (QCM) to investigate live-cell activity in water-based toxic solutions. The QCM used in this research has a resonant frequency of 10 MHz and consists of an AT-cut quartz crystal with gold electrodes on both sides. This QCM was t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English English |
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American Institute of Physics Inc.
2020
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| Online Access: | http://irep.iium.edu.my/82225/ http://irep.iium.edu.my/82225/19/82225_MEMS%20biosensor%20for%20monitoring%20water.pdf http://irep.iium.edu.my/82225/2/82225_MEMS%20biosensor%20for%20monitoring_SCOPUS.pdf http://irep.iium.edu.my/82225/3/82225_MEMS%20biosensor%20for%20monitoring_WOS.pdf |
| _version_ | 1848789262481227776 |
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| author | Kun-Lin, Lee Ng, Simon Li, Fang Nordin, Anis Nurashikin Voiculescu, Ioana |
| author_facet | Kun-Lin, Lee Ng, Simon Li, Fang Nordin, Anis Nurashikin Voiculescu, Ioana |
| author_sort | Kun-Lin, Lee |
| building | IIUM Repository |
| collection | Online Access |
| description | This paper presents the use of a commercial quartz crystal microbalance (QCM) to investigate live-cell activity in water-based toxic solutions. The QCM used in this research has a resonant frequency of 10 MHz and consists of an AT-cut quartz crystal with gold electrodes on both sides. This QCM was transformed into a functional biosensor by integrating with polydimethylsiloxane culturing chambers. Rainbow trout gill epithelial cells were cultured on the resonators as a sensorial layer. The fluctuation of the resonant frequency, due to the change of cell morphology and adhesion, is an indicator of water toxicity. The shift in the resonant frequency provides information about the viability of the cells after exposure to toxicants. The toxicity result shows distinct responses after exposing cells to 0.526 μM of pentachlorophenol (PCP) solution, which is the Military Exposure Guidelines concentration. This research demonstrated that the QCM is sensitive to a low concentration of PCP and no further modification of the QCM surface was required. |
| first_indexed | 2025-11-14T17:53:56Z |
| format | Article |
| id | iium-82225 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:53:56Z |
| publishDate | 2020 |
| publisher | American Institute of Physics Inc. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-822252020-08-24T09:07:04Z http://irep.iium.edu.my/82225/ MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance Kun-Lin, Lee Ng, Simon Li, Fang Nordin, Anis Nurashikin Voiculescu, Ioana TK Electrical engineering. Electronics Nuclear engineering TK4001 Applications of electric power This paper presents the use of a commercial quartz crystal microbalance (QCM) to investigate live-cell activity in water-based toxic solutions. The QCM used in this research has a resonant frequency of 10 MHz and consists of an AT-cut quartz crystal with gold electrodes on both sides. This QCM was transformed into a functional biosensor by integrating with polydimethylsiloxane culturing chambers. Rainbow trout gill epithelial cells were cultured on the resonators as a sensorial layer. The fluctuation of the resonant frequency, due to the change of cell morphology and adhesion, is an indicator of water toxicity. The shift in the resonant frequency provides information about the viability of the cells after exposure to toxicants. The toxicity result shows distinct responses after exposing cells to 0.526 μM of pentachlorophenol (PCP) solution, which is the Military Exposure Guidelines concentration. This research demonstrated that the QCM is sensitive to a low concentration of PCP and no further modification of the QCM surface was required. American Institute of Physics Inc. 2020-03-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/82225/19/82225_MEMS%20biosensor%20for%20monitoring%20water.pdf application/pdf en http://irep.iium.edu.my/82225/2/82225_MEMS%20biosensor%20for%20monitoring_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/82225/3/82225_MEMS%20biosensor%20for%20monitoring_WOS.pdf Kun-Lin, Lee and Ng, Simon and Li, Fang and Nordin, Anis Nurashikin and Voiculescu, Ioana (2020) MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance. Biointerphases, 15 (2). pp. 1-3. ISSN 1934-8630 E-ISSN 1559-4106 https://avs.scitation.org/doi/10.1116/1.5142722 10.1116/1.5142722 |
| spellingShingle | TK Electrical engineering. Electronics Nuclear engineering TK4001 Applications of electric power Kun-Lin, Lee Ng, Simon Li, Fang Nordin, Anis Nurashikin Voiculescu, Ioana MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance |
| title | MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance |
| title_full | MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance |
| title_fullStr | MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance |
| title_full_unstemmed | MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance |
| title_short | MEMS biosensor for monitoring water toxicity based on quartz crystal microbalance |
| title_sort | mems biosensor for monitoring water toxicity based on quartz crystal microbalance |
| topic | TK Electrical engineering. Electronics Nuclear engineering TK4001 Applications of electric power |
| url | http://irep.iium.edu.my/82225/ http://irep.iium.edu.my/82225/ http://irep.iium.edu.my/82225/ http://irep.iium.edu.my/82225/19/82225_MEMS%20biosensor%20for%20monitoring%20water.pdf http://irep.iium.edu.my/82225/2/82225_MEMS%20biosensor%20for%20monitoring_SCOPUS.pdf http://irep.iium.edu.my/82225/3/82225_MEMS%20biosensor%20for%20monitoring_WOS.pdf |