Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin
The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium al...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
MDPI AG
2020
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| Online Access: | http://irep.iium.edu.my/80929/ http://irep.iium.edu.my/80929/1/molecules-25-02244.pdf http://irep.iium.edu.my/80929/7/Scopus%20-formulation%20characterization.pdf |
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| author | Hassani, Abdelkader Mahmood, Syed Enezei, Hamid Hammad Hussain, Siti Aslina Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel |
| author_facet | Hassani, Abdelkader Mahmood, Syed Enezei, Hamid Hammad Hussain, Siti Aslina Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel |
| author_sort | Hassani, Abdelkader |
| building | IIUM Repository |
| collection | Online Access |
| description | The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared
using the ionotropic gelation technique and further subjected to physico-chemical characterization
using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD),
differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM).
The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against
human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer
(MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties
that might aid in future cancer therapy |
| first_indexed | 2025-11-14T17:50:31Z |
| format | Article |
| id | iium-80929 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:50:31Z |
| publishDate | 2020 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-809292020-11-18T07:45:15Z http://irep.iium.edu.my/80929/ Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin Hassani, Abdelkader Mahmood, Syed Enezei, Hamid Hammad Hussain, Siti Aslina Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel RS Pharmacy and materia medica The approach of drug delivery systems emphasizes the use of nanoparticles as a vehicle, offering the optional property of delivering drugs as a single dose rather than in multiple doses. The current study aims to improve antioxidant and drug release properties of curcumin loaded gum Arabic-sodium alginate nanoparticles (Cur/ALG-GANPs). The Cur/ALG-GANPs were prepared using the ionotropic gelation technique and further subjected to physico-chemical characterization using attenuated total reflectance–Fourier transform infrared (ATR-FTIR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), size distribution, and transmission electron microscopy (TEM). The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was –15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. Thus, this study indicates that Cur/ALG-GANPs have promising anticancer properties that might aid in future cancer therapy MDPI AG 2020-05-01 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/80929/1/molecules-25-02244.pdf application/pdf en http://irep.iium.edu.my/80929/7/Scopus%20-formulation%20characterization.pdf Hassani, Abdelkader and Mahmood, Syed and Enezei, Hamid Hammad and Hussain, Siti Aslina and Hamad, Hamad Ali and Aldoghachi, Ahmed Faris and Hagar, Abdullah and Doolaanea, Abd Almonem and Ibrahim, Wisam Nabeel (2020) Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin. Molecules, 25 (9). pp. 1-21. ISSN 1420-3049 https://www.mdpi.com/1420-3049/25/9/2244 doi:10.3390/molecules25092244 |
| spellingShingle | RS Pharmacy and materia medica Hassani, Abdelkader Mahmood, Syed Enezei, Hamid Hammad Hussain, Siti Aslina Hamad, Hamad Ali Aldoghachi, Ahmed Faris Hagar, Abdullah Doolaanea, Abd Almonem Ibrahim, Wisam Nabeel Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin |
| title | Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin |
| title_full | Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin |
| title_fullStr | Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin |
| title_full_unstemmed | Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin |
| title_short | Formulation, characterization and biological activity screening of sodium alginate-gum Arabic nanoparticles loaded with curcumin |
| title_sort | formulation, characterization and biological activity screening of sodium alginate-gum arabic nanoparticles loaded with curcumin |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/80929/ http://irep.iium.edu.my/80929/ http://irep.iium.edu.my/80929/ http://irep.iium.edu.my/80929/1/molecules-25-02244.pdf http://irep.iium.edu.my/80929/7/Scopus%20-formulation%20characterization.pdf |