Taste masking of paracetamol encapsulated in chitosan-coated alginate beads
Taste masking is required for bitter drugs to enhance patient compliance, especially among the paediatric population. Paracetamol, the first line for paediatricians to treat pain and fever, is known for its bitter taste. This study aimed to mask the bitter taste of paracetamol and explore the poten...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Editions de Sante
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/80927/ http://irep.iium.edu.my/80927/1/1-s2.0-S1773224719315771-main.pdf http://irep.iium.edu.my/80927/7/Scopus%20-%20Taste%20masking%20of%20paracetamol%20encapsulated%20in%20chitosan-coated%20alginate.pdf |
| Summary: | Taste masking is required for bitter drugs to enhance patient compliance, especially among the paediatric population. Paracetamol, the first line for paediatricians to treat pain and fever, is known for its bitter taste. This
study aimed to mask the bitter taste of paracetamol and explore the potential of alginate microencapsulation in
palatability improvement. Chitosan-coated paracetamol alginate beads were optimised using electrospray to
obtain spherical beads with size below 1.5 mm. The encapsulation efficiency (EE) of the uncoated beads decreased with increased gelation time to reach 5 ± 1.32% at 60 min. Chitosan coating enhanced EE to 50–76%
depending on chitosan type and concentration. EE significantly improved to 99.0 ± 1.1% by saturating the
gelation bath with paracetamol. In vitro taste masking test and in vivo palatability evaluation using 12 human
volunteers demonstrated that dry chitosan-coated paracetamol alginate beads were superior to the wet ones for taste masking, which was similar to the marketed paracetamol suspension and even better in aftertaste evaluation. This indicates that the microencapsulation in alginate with further chitosan coating can compensate for
the usage of sweetening and flavouring agents. This helps to formulate paediatric dosage forms with minimal
undesired excipients |
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