Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain
Neurogenesis involves cell proliferation, cell cycle arrest, differentiation, migration and the natural developmental death of the neural precursors. These processes are highly co-ordinated and governed by cell-cycle genes and neural transcription factors. Zn plays a crucial role as a functional...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Maney Publishing
2009
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| Online Access: | http://irep.iium.edu.my/806/ http://irep.iium.edu.my/806/1/Zinc_intake_during_pregnancy_increases_the_proliferation_at_ventricular_zone_of_the_newborn_brain.pdf |
| _version_ | 1848775760880336896 |
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| author | Azman, Mohd S. Wan Saudi, Wan S. Ilhami, Mohammad Abdul Mutalib, Mohd Sokhini Rahman, Muhammad Tariqur |
| author_facet | Azman, Mohd S. Wan Saudi, Wan S. Ilhami, Mohammad Abdul Mutalib, Mohd Sokhini Rahman, Muhammad Tariqur |
| author_sort | Azman, Mohd S. |
| building | IIUM Repository |
| collection | Online Access |
| description | Neurogenesis involves cell proliferation, cell cycle arrest, differentiation, migration and the natural
developmental death of the neural precursors. These processes are highly co-ordinated and
governed by cell-cycle genes and neural transcription factors. Zn plays a crucial role as a functional
and structural component of enzymes and transcription factors and components of the intracellular
signaling pathway associated with the regulation of cell proliferation. The influence of additional Zn
intake during pregnancy on the neuronal proliferation at ventricular zone of the developing fetus has been studied. Pups delivered by the group of mice provided with drinking water with 4.0 mM Zn supplement throughout pregnancy contained an increased number of proliferating neurons in the ventricular zone at P0 compared to those delivered by the mice provided with drinking water without any Zn supplement. This finding provides direct evidence to support the notion that maternal Zn levels influence the development of the nervous system of the offspring. |
| first_indexed | 2025-11-14T14:19:19Z |
| format | Article |
| id | iium-806 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:19:19Z |
| publishDate | 2009 |
| publisher | Maney Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-8062011-06-30T07:54:22Z http://irep.iium.edu.my/806/ Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain Azman, Mohd S. Wan Saudi, Wan S. Ilhami, Mohammad Abdul Mutalib, Mohd Sokhini Rahman, Muhammad Tariqur RG Gynecology and obstetrics Neurogenesis involves cell proliferation, cell cycle arrest, differentiation, migration and the natural developmental death of the neural precursors. These processes are highly co-ordinated and governed by cell-cycle genes and neural transcription factors. Zn plays a crucial role as a functional and structural component of enzymes and transcription factors and components of the intracellular signaling pathway associated with the regulation of cell proliferation. The influence of additional Zn intake during pregnancy on the neuronal proliferation at ventricular zone of the developing fetus has been studied. Pups delivered by the group of mice provided with drinking water with 4.0 mM Zn supplement throughout pregnancy contained an increased number of proliferating neurons in the ventricular zone at P0 compared to those delivered by the mice provided with drinking water without any Zn supplement. This finding provides direct evidence to support the notion that maternal Zn levels influence the development of the nervous system of the offspring. Maney Publishing 2009 Article PeerReviewed application/pdf en http://irep.iium.edu.my/806/1/Zinc_intake_during_pregnancy_increases_the_proliferation_at_ventricular_zone_of_the_newborn_brain.pdf Azman, Mohd S. and Wan Saudi, Wan S. and Ilhami, Mohammad and Abdul Mutalib, Mohd Sokhini and Rahman, Muhammad Tariqur (2009) Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain. Nutritional Neuroscience, 12 (1). pp. 9-12. ISSN 1476-8305 http://www.maney.co.uk/index.php/journals/nns/?back=1 DOI: 10.1179/147683009X388904 |
| spellingShingle | RG Gynecology and obstetrics Azman, Mohd S. Wan Saudi, Wan S. Ilhami, Mohammad Abdul Mutalib, Mohd Sokhini Rahman, Muhammad Tariqur Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain |
| title | Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain |
| title_full | Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain |
| title_fullStr | Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain |
| title_full_unstemmed | Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain |
| title_short | Zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain |
| title_sort | zinc intake during the pregnancy increases the proliferation at ventricular zone of the newborn brain |
| topic | RG Gynecology and obstetrics |
| url | http://irep.iium.edu.my/806/ http://irep.iium.edu.my/806/ http://irep.iium.edu.my/806/ http://irep.iium.edu.my/806/1/Zinc_intake_during_pregnancy_increases_the_proliferation_at_ventricular_zone_of_the_newborn_brain.pdf |