Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model
Introduction:The aim of this study was to evaluate the effect protein containing adiponectin from the adipocytes on the regeneration of pancreatic β-cells in rates previously treated with (STZ). Therefore, adipocytes from different sources were extracted for protein (adipokines) and the effect wa...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MedCrave
2020
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/80434/ http://irep.iium.edu.my/80434/1/AOWMC-10-00302.pdf |
| _version_ | 1848788957324640256 |
|---|---|
| author | Azahari, Nuraniza Mohd Shukri, Nor Azwani Khattak, Muhammad Muzaffar Ali Khan |
| author_facet | Azahari, Nuraniza Mohd Shukri, Nor Azwani Khattak, Muhammad Muzaffar Ali Khan |
| author_sort | Azahari, Nuraniza |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction:The aim of this study was to evaluate the effect protein containing adiponectin
from the adipocytes on the regeneration of pancreatic β-cells in rates previously treated with
(STZ). Therefore, adipocytes from different sources were extracted for protein (adipokines)
and the effect was evaluated on pancreatic β-cell regeneration.
Methods: The protein extracts from trimmed off abdominal adipose tissues of meat
sources, namely chicken, beef and lamb, were used in the present study. The fats were
removed, and protein were isolated, and hydrolysate were prepared and injected to rats.
The rats were induced hyperglycemia with streptozotocin (STZ) were divided into normal
rats (Group-A), insulin treated rats (Group-B), protein containing beef adiponectin (PCBA)
(Group-C), protein containing lamb adiponectin (PCLA) (Group-D), protein containing
chicken adiponectin (PCCA) (Group-E) and no treatment hyperglycemic rats (Group-F).
The rats were injected 30mg of the aforementioned proteins and pancreatic morphology
was assessed two weeks post-treatment.
Results: The pancreas of the Group-A showed normal islets of Langerhans with abundant
beta cells. In the no treatment rats (Group-F), islets were lower in cellular density compared
to the control and treatment groups. The pancreas of Group-C, D and E rats showed islets
and acinar cells that were comparable to the control. The pancreas of insulin-treated
Group-B was similar in architecture to the control group.
Conclusions:The present study indicates that protein extracts containing adipokines from
Adipocytes Containing Adiponectin Causes β-cell Regeneration in Rats |
| first_indexed | 2025-11-14T17:49:04Z |
| format | Article |
| id | iium-80434 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:49:04Z |
| publishDate | 2020 |
| publisher | MedCrave |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-804342022-12-09T03:53:41Z http://irep.iium.edu.my/80434/ Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model Azahari, Nuraniza Mohd Shukri, Nor Azwani Khattak, Muhammad Muzaffar Ali Khan RM216 Diet Therapy. Clinical Nutrition TX Home economics TX341 Nutrition. Foods and food supply Introduction:The aim of this study was to evaluate the effect protein containing adiponectin from the adipocytes on the regeneration of pancreatic β-cells in rates previously treated with (STZ). Therefore, adipocytes from different sources were extracted for protein (adipokines) and the effect was evaluated on pancreatic β-cell regeneration. Methods: The protein extracts from trimmed off abdominal adipose tissues of meat sources, namely chicken, beef and lamb, were used in the present study. The fats were removed, and protein were isolated, and hydrolysate were prepared and injected to rats. The rats were induced hyperglycemia with streptozotocin (STZ) were divided into normal rats (Group-A), insulin treated rats (Group-B), protein containing beef adiponectin (PCBA) (Group-C), protein containing lamb adiponectin (PCLA) (Group-D), protein containing chicken adiponectin (PCCA) (Group-E) and no treatment hyperglycemic rats (Group-F). The rats were injected 30mg of the aforementioned proteins and pancreatic morphology was assessed two weeks post-treatment. Results: The pancreas of the Group-A showed normal islets of Langerhans with abundant beta cells. In the no treatment rats (Group-F), islets were lower in cellular density compared to the control and treatment groups. The pancreas of Group-C, D and E rats showed islets and acinar cells that were comparable to the control. The pancreas of insulin-treated Group-B was similar in architecture to the control group. Conclusions:The present study indicates that protein extracts containing adipokines from Adipocytes Containing Adiponectin Causes β-cell Regeneration in Rats MedCrave 2020 Article PeerReviewed application/pdf en http://irep.iium.edu.my/80434/1/AOWMC-10-00302.pdf Azahari, Nuraniza and Mohd Shukri, Nor Azwani and Khattak, Muhammad Muzaffar Ali Khan (2020) Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model. Advances in Obesity, Weight Management & Control, 10 (2). pp. 33-38. E-ISSN 2378-3168 https://medcraveonline.com/AOWMC/AOWMC-10-00302.pdf 10.15406/aowmc.2020.10.00302 |
| spellingShingle | RM216 Diet Therapy. Clinical Nutrition TX Home economics TX341 Nutrition. Foods and food supply Azahari, Nuraniza Mohd Shukri, Nor Azwani Khattak, Muhammad Muzaffar Ali Khan Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model |
| title | Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model |
| title_full | Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model |
| title_fullStr | Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model |
| title_full_unstemmed | Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model |
| title_short | Adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model |
| title_sort | adipocytes containing adipokines causes β-cell regeneration in previously streptozotocin induced hyperglycemic rats model |
| topic | RM216 Diet Therapy. Clinical Nutrition TX Home economics TX341 Nutrition. Foods and food supply |
| url | http://irep.iium.edu.my/80434/ http://irep.iium.edu.my/80434/ http://irep.iium.edu.my/80434/ http://irep.iium.edu.my/80434/1/AOWMC-10-00302.pdf |