Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis
Introduction. Chronic and post-prandial hyperglycemia are independent risk factors for diabetic complications. Glycemic patterns among hemodialysis end-stage-renal-disease (ESRD) differ as glucose metabolism changes with declining kidney function with more pronounced glycemic fluctuations. The objec...
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| Format: | Article |
| Language: | English |
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ASEAN Federation of Endocrine Societies (AFES)
2020
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| Online Access: | http://irep.iium.edu.my/80385/ http://irep.iium.edu.my/80385/1/80385_Glycemic%20Patterns%20and%20Factors%20Associated.pdf |
| _version_ | 1848788947530940416 |
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| author | Yusof Khan, Abdul Hanif Khan Zainal Abidin, Muhammad 'Adil Zakaria, Nor Fadhlina Seong Ling, Christopher Tiam Kamaruddin, Nor Azmi |
| author_facet | Yusof Khan, Abdul Hanif Khan Zainal Abidin, Muhammad 'Adil Zakaria, Nor Fadhlina Seong Ling, Christopher Tiam Kamaruddin, Nor Azmi |
| author_sort | Yusof Khan, Abdul Hanif Khan |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction. Chronic and post-prandial hyperglycemia are independent risk factors for diabetic complications. Glycemic patterns among hemodialysis end-stage-renal-disease (ESRD) differ as glucose metabolism changes with declining kidney function with more pronounced glycemic fluctuations. The objectives of this study are to determine glycemic patterns on hemodialysis days, the magnitude of post-hemodialysis rebound hyperglycemia (PHH) and their associated factors.
Methodology. 148 patients on hemodialysis were analysed, 91 patients had end-stage-diabetic-renal disease (DM-ESRD), and 57 patients had end-stage-non-diabetic renal disease (NDM-ESRD). Glycemic patterns and PHH data were obtained from 11-point and 7-point self-monitoring blood glucose (SMBG) profiles on hemodialysis and
non-hemodialysis days. PHH and its associated factors were analysed with logistic regression.
Results. Mean blood glucose on hemodialysis days was 9.33 [SD 2.7] mmol/L in DM-ESRD patients compared to 6.07 [SD 0.85] mmol/L in those with NDM-ESRD (p<0.001). PHH occurred in 70% of patients and was more pronounced in DM-ESRD compared to NDM-ESRD patients (72.5% vs 27.5%; OR 4.5). Asymptomatic hypoglycemia was observed
in 18% of patients. DM-ESRD, older age, previous IHD, obesity, high HbA1c, elevated highly-sensitive CRP and low albumin were associated with PHH.
Conclusion. DM-ESRD patients experienced significant PHH in our cohort. Other associated factors include older age, previous IHD, obesity, high HbA1c, elevated hs-CRP and low albumin. |
| first_indexed | 2025-11-14T17:48:55Z |
| format | Article |
| id | iium-80385 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:48:55Z |
| publishDate | 2020 |
| publisher | ASEAN Federation of Endocrine Societies (AFES) |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-803852021-01-29T02:50:09Z http://irep.iium.edu.my/80385/ Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis Yusof Khan, Abdul Hanif Khan Zainal Abidin, Muhammad 'Adil Zakaria, Nor Fadhlina Seong Ling, Christopher Tiam Kamaruddin, Nor Azmi RC627 Specialties of Internal Medicine-Metabolic Diseases RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology Introduction. Chronic and post-prandial hyperglycemia are independent risk factors for diabetic complications. Glycemic patterns among hemodialysis end-stage-renal-disease (ESRD) differ as glucose metabolism changes with declining kidney function with more pronounced glycemic fluctuations. The objectives of this study are to determine glycemic patterns on hemodialysis days, the magnitude of post-hemodialysis rebound hyperglycemia (PHH) and their associated factors. Methodology. 148 patients on hemodialysis were analysed, 91 patients had end-stage-diabetic-renal disease (DM-ESRD), and 57 patients had end-stage-non-diabetic renal disease (NDM-ESRD). Glycemic patterns and PHH data were obtained from 11-point and 7-point self-monitoring blood glucose (SMBG) profiles on hemodialysis and non-hemodialysis days. PHH and its associated factors were analysed with logistic regression. Results. Mean blood glucose on hemodialysis days was 9.33 [SD 2.7] mmol/L in DM-ESRD patients compared to 6.07 [SD 0.85] mmol/L in those with NDM-ESRD (p<0.001). PHH occurred in 70% of patients and was more pronounced in DM-ESRD compared to NDM-ESRD patients (72.5% vs 27.5%; OR 4.5). Asymptomatic hypoglycemia was observed in 18% of patients. DM-ESRD, older age, previous IHD, obesity, high HbA1c, elevated highly-sensitive CRP and low albumin were associated with PHH. Conclusion. DM-ESRD patients experienced significant PHH in our cohort. Other associated factors include older age, previous IHD, obesity, high HbA1c, elevated hs-CRP and low albumin. ASEAN Federation of Endocrine Societies (AFES) 2020-05-02 Article PeerReviewed application/pdf en http://irep.iium.edu.my/80385/1/80385_Glycemic%20Patterns%20and%20Factors%20Associated.pdf Yusof Khan, Abdul Hanif Khan and Zainal Abidin, Muhammad 'Adil and Zakaria, Nor Fadhlina and Seong Ling, Christopher Tiam and Kamaruddin, Nor Azmi (2020) Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis. Journal of the ASEAN Federation of Endocrine Societies (JAFES), 35 (1). pp. 43-51. ISSN 0857-1074 E-ISSN 2308-118x https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/769 |
| spellingShingle | RC627 Specialties of Internal Medicine-Metabolic Diseases RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology Yusof Khan, Abdul Hanif Khan Zainal Abidin, Muhammad 'Adil Zakaria, Nor Fadhlina Seong Ling, Christopher Tiam Kamaruddin, Nor Azmi Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis |
| title | Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis |
| title_full | Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis |
| title_fullStr | Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis |
| title_full_unstemmed | Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis |
| title_short | Glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sStage-renal disease patients undergoing maintenance hemodialysis |
| title_sort | glycemic patterns and factors associated with post-hemodialysis hyperglycemia among end-sstage-renal disease patients undergoing maintenance hemodialysis |
| topic | RC627 Specialties of Internal Medicine-Metabolic Diseases RC648 Specialties of Internal Medicine-Diseases of The Endocrine Glands. Clinical Endocrinology |
| url | http://irep.iium.edu.my/80385/ http://irep.iium.edu.my/80385/ http://irep.iium.edu.my/80385/1/80385_Glycemic%20Patterns%20and%20Factors%20Associated.pdf |